Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, a...

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Bibliographic Details
Main Authors: Maria E Falzone, Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh M Raczkowski, Edward T Eng, Annarita Di Lorenzo, Olaf S Andersen, Crina M Nimigean, Alessio Accardi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Scrambling
membrane structure
membrane channels
phospholipids
Online Access:https://elifesciences.org/articles/43229

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