Clinical effect of terbutaline injection aerosol inhalation combined with conventional drug therapy for acute attack of bronchial asthma in children

• Main Authors: Jun Lei, Kai-Feng Liu, Xiao-Hong Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-07-01
• Series: Journal of Hainan Medical University
• Subjects: Bronchial asthma; Terbutaline; Immune response; Inflammatory response; Protease
• Online Access: http://www.hnykdxxb.com/PDF/201807/12.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the clinical effect of terbutaline injection aerosol inhalation combined with conventional drug therapy for acute attack of bronchial asthma in children. Methods: Children with acute attack of bronchial asthma who were treated in Wusheng Hospital of Traditional Chinese Medicine and Qiandongnan Prefecture People's Hospital between January 2014 and July 2017 were selected as the study cases for prospective study and randomly divided into the experimental group who received terbutaline + budesonide aerosol inhalation and the control group who received budesonide aerosol inhalation. The expression levels of immune cell transcription factors in peripheral blood as well as the contents of adhesion factors, chemokines, proteases and their inhibitory molecules in serum were determined before treatment and 3 days after treatment. Results: Foxp3 and T-bet expression in peripheral blood as well as TIMP1 and TIMP2 contents in serum of both groups after treatment were higher than those before treatment whereas RORγt and GATA-3 expression in peripheral blood as well as TARC, Eotaxin, ICAM-1, VCAM-1, L-selectin, ADAM8, NE and MMP9 contents in serum were lower than those before treatment, and Foxp3 and T-bet expression in peripheral blood as well as TIMP1 and TIMP2 contents in serum of experimental group after treatment were higher than those of control group whereas RORγt and GATA-3 expression in peripheral blood as well as TARC, Eotaxin, ICAM-1, VCAM-1, L-selectin, ADAM8, NE and MMP9 contents in serum were lower than those of control group. Conclusion: Terbutaline injection aerosol inhalation combined with conventional drug therapy can effectively regulate the immune response and inflammatory response and inhibit the airway remodeling mediated by protease in children with acute attack of bronchial asthma.