Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania
Leishmaniasis is a serious threat in developing countries due to its endemic nature and debilitating symptoms. Extensive research and investigations have been carried out to learn about the mechanism of drug resistance in Leishmania but results obtained in the laboratory are not in agreement with th...
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doaj-d90e6b3ce4cd4f768582aedc4451c9ac2020-11-24T21:31:53ZengHindawi LimitedJournal of Parasitology Research2090-00232090-00312014-01-01201410.1155/2014/726328726328Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in LeishmaniaGagandeep Kaur0Bhawana Rajput1University Avenue, College of Medical, Veterinary and Life Sciences, University of Glasgow, Lanarkshire G12 8Q, UKUniversity Avenue, College of Medical, Veterinary and Life Sciences, University of Glasgow, Lanarkshire G12 8Q, UKLeishmaniasis is a serious threat in developing countries due to its endemic nature and debilitating symptoms. Extensive research and investigations have been carried out to learn about the mechanism of drug resistance in Leishmania but results obtained in the laboratory are not in agreement with those obtained from the field. Also the lack of knowledge about the mode of action for a number of drugs makes the study of drug resistance more complex. A major concern in recent times has been regarding the role of parasitic virulence in drug resistance for Leishmania. Researchers have employed various techniques to unravel the facts about resistance and virulence in Leishmania. With advent of advanced and more specific means of detection, further hints about probable mechanisms of conferring resistance are expected. This review aims to provide a consolidated picture along with a comparative account of the work done so far to study the mechanism of antimony, amphotericin B, and pentamidine resistance using various techniques.http://dx.doi.org/10.1155/2014/726328 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gagandeep Kaur Bhawana Rajput |
spellingShingle |
Gagandeep Kaur Bhawana Rajput Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania Journal of Parasitology Research |
author_facet |
Gagandeep Kaur Bhawana Rajput |
author_sort |
Gagandeep Kaur |
title |
Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania |
title_short |
Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania |
title_full |
Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania |
title_fullStr |
Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania |
title_full_unstemmed |
Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania |
title_sort |
comparative analysis of the omics technologies used to study antimonial, amphotericin b, and pentamidine resistance in leishmania |
publisher |
Hindawi Limited |
series |
Journal of Parasitology Research |
issn |
2090-0023 2090-0031 |
publishDate |
2014-01-01 |
description |
Leishmaniasis is a serious threat in developing countries due to its endemic nature and debilitating symptoms. Extensive research and investigations have been carried out to learn about the mechanism of drug resistance in Leishmania but results obtained in the laboratory are not in agreement with those obtained from the field. Also the lack of knowledge about the mode of action for a number of drugs makes the study of drug resistance more complex. A major concern in recent times has been regarding the role of parasitic virulence in drug resistance for Leishmania. Researchers have employed various techniques to unravel the facts about resistance and virulence in Leishmania. With advent of advanced and more specific means of detection, further hints about probable mechanisms of conferring resistance are expected. This review aims to provide a consolidated picture along with a comparative account of the work done so far to study the mechanism of antimony, amphotericin B, and pentamidine resistance using various techniques. |
url |
http://dx.doi.org/10.1155/2014/726328 |
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