Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle

Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle

Background: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited. Objective: The present study aimed to evaluate the impact of chronic stress on th...

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Main Authors: Fahiel Casillas, Miguel Betancourt, Lizbeth Juárez-Rojas, Yvonne Ducolomb, Alma López, Alejandra Ávila-Quintero, Jimena Zamora, Mohammad Mehdi Ommati, Socorro Retana-Márquez
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Animals
Subjects:
cold stress
female cycles
homeostasis
oogenesis
ovum
Online Access:https://www.mdpi.com/2076-2615/11/9/2478
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spelling doaj-d9237ccf03854c9281e9cfe509a2e1af2021-09-25T23:35:15ZengMDPI AGAnimals2076-26152021-08-01112478247810.3390/ani11092478Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous CycleFahiel Casillas0Miguel Betancourt1Lizbeth Juárez-Rojas2Yvonne Ducolomb3Alma López4Alejandra Ávila-Quintero5Jimena Zamora6Mohammad Mehdi Ommati7Socorro Retana-Márquez8Department of Biology of Reproduction, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Health Sciences, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Biology of Reproduction, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Health Sciences, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Health Sciences, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Biology of Reproduction, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Biology of Reproduction, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoDepartment of Bioinformatics, College of Life Sciences, Shanxi Agricultural University, Jinzhong 030801, ChinaDepartment of Biology of Reproduction, Iztapalapa Campus, Metropolitan Autonomous University, Mexico City 09340, MexicoBackground: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited. Objective: The present study aimed to evaluate the impact of chronic stress on the viability, integrity, and maturation of rat oocytes depending on estrous cycle phases, specifically proestrus, estrus, and diestrus. Methods: For this purpose, adult female rats were stressed daily by cold water immersion (15 °C) for 30 consecutive days. Results: In chronically stressed female rats, irregular estrous cyclicity, increased corticosterone levels, decreased oocyte viability, and an increased percentage of abnormal oocytes were obtained in all the estrous cycle phases, resulting in reduced oocyte maturation during proestrus. Conclusion: Oocyte maturation disturbed by chronic stress is a crucial factor by which chronic stress disrupts female reproductionhttps://www.mdpi.com/2076-2615/11/9/2478cold stressfemale cycleshomeostasisoogenesisovum
collection DOAJ
language English
format Article
sources DOAJ
author Fahiel Casillas
Miguel Betancourt
Lizbeth Juárez-Rojas
Yvonne Ducolomb
Alma López
Alejandra Ávila-Quintero
Jimena Zamora
Mohammad Mehdi Ommati
Socorro Retana-Márquez
spellingShingle Fahiel Casillas
Miguel Betancourt
Lizbeth Juárez-Rojas
Yvonne Ducolomb
Alma López
Alejandra Ávila-Quintero
Jimena Zamora
Mohammad Mehdi Ommati
Socorro Retana-Márquez
Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
Animals
cold stress
female cycles
homeostasis
oogenesis
ovum
author_facet Fahiel Casillas
Miguel Betancourt
Lizbeth Juárez-Rojas
Yvonne Ducolomb
Alma López
Alejandra Ávila-Quintero
Jimena Zamora
Mohammad Mehdi Ommati
Socorro Retana-Márquez
author_sort Fahiel Casillas
title Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
title_short Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
title_full Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
title_fullStr Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
title_full_unstemmed Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
title_sort chronic stress detrimentally affects in vivo maturation in rat oocytes and oocyte viability at all phases of the estrous cycle
publisher MDPI AG
series Animals
issn 2076-2615
publishDate 2021-08-01
description Background: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited. Objective: The present study aimed to evaluate the impact of chronic stress on the viability, integrity, and maturation of rat oocytes depending on estrous cycle phases, specifically proestrus, estrus, and diestrus. Methods: For this purpose, adult female rats were stressed daily by cold water immersion (15 °C) for 30 consecutive days. Results: In chronically stressed female rats, irregular estrous cyclicity, increased corticosterone levels, decreased oocyte viability, and an increased percentage of abnormal oocytes were obtained in all the estrous cycle phases, resulting in reduced oocyte maturation during proestrus. Conclusion: Oocyte maturation disturbed by chronic stress is a crucial factor by which chronic stress disrupts female reproduction
topic cold stress
female cycles
homeostasis
oogenesis
ovum
url https://www.mdpi.com/2076-2615/11/9/2478
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AT miguelbetancourt chronicstressdetrimentallyaffectsinvivomaturationinratoocytesandoocyteviabilityatallphasesoftheestrouscycle
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