The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis
C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with β2-glycoprotein I (β2GPI), implicating oxLDL/β2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascula...
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Format: | Article |
Language: | English |
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Elsevier
2007-04-01
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Series: | Journal of Lipid Research |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520434303 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masako Tabuchi Katsumi Inoue Hitomi Usui-Kataoka Kazuko Kobayashi Misako Teramoto Koji Takasugi Kenichi Shikata Masahiro Yamamura Kenji Ando Keiichiro Nishida Junko Kasahara Noriaki Kume Luis R. Lopez Kazuaki Mitsudo Masakiyo Nobuyoshi Tatsuji Yasuda Toru Kita Hirofumi Makino Eiji Matsuura |
spellingShingle |
Masako Tabuchi Katsumi Inoue Hitomi Usui-Kataoka Kazuko Kobayashi Misako Teramoto Koji Takasugi Kenichi Shikata Masahiro Yamamura Kenji Ando Keiichiro Nishida Junko Kasahara Noriaki Kume Luis R. Lopez Kazuaki Mitsudo Masakiyo Nobuyoshi Tatsuji Yasuda Toru Kita Hirofumi Makino Eiji Matsuura The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis Journal of Lipid Research β2-glycoprotein I oxidized LDL/β2-glycoprotein I complexes diabetes mellitus oxidized LDL |
author_facet |
Masako Tabuchi Katsumi Inoue Hitomi Usui-Kataoka Kazuko Kobayashi Misako Teramoto Koji Takasugi Kenichi Shikata Masahiro Yamamura Kenji Ando Keiichiro Nishida Junko Kasahara Noriaki Kume Luis R. Lopez Kazuaki Mitsudo Masakiyo Nobuyoshi Tatsuji Yasuda Toru Kita Hirofumi Makino Eiji Matsuura |
author_sort |
Masako Tabuchi |
title |
The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis |
title_short |
The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis |
title_full |
The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis |
title_fullStr |
The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis |
title_full_unstemmed |
The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis |
title_sort |
association of c-reactive protein with an oxidative metabolite of ldl and its implication in atherosclerosis |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2007-04-01 |
description |
C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with β2-glycoprotein I (β2GPI), implicating oxLDL/β2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/β2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/β2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and β2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of atherosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/β2GPI complexes correlated with total cholesterol and hemoglobin A1c. Thus, the generation of CRP/oxLDL/β2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/β2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis. |
topic |
β2-glycoprotein I oxidized LDL/β2-glycoprotein I complexes diabetes mellitus oxidized LDL |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520434303 |
work_keys_str_mv |
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doaj-d924040b5d074996b1803f8ab213dcc32021-04-27T04:47:38ZengElsevierJournal of Lipid Research0022-22752007-04-01484768781The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosisMasako Tabuchi0Katsumi Inoue1Hitomi Usui-Kataoka2Kazuko Kobayashi3Misako Teramoto4Koji Takasugi5Kenichi Shikata6Masahiro Yamamura7Kenji Ando8Keiichiro Nishida9Junko Kasahara10Noriaki Kume11Luis R. Lopez12Kazuaki Mitsudo13Masakiyo Nobuyoshi14Tatsuji Yasuda15Toru Kita16Hirofumi Makino17Eiji Matsuura18Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Pathology, Kokura Memorial Hospital, Kitakyushu 802-8555, Japan; Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki 710-8602, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Pathology, Kokura Memorial Hospital, Kitakyushu 802-8555, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu 802-8555, JapanDepartment of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Internal Medicine, Okayama Central Hospital, Okayama 700-0017, JapanDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8501, JapanCorgenix, Inc., Broomfield, CO 80020Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki 710-8602, JapanDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu 802-8555, JapanDepartment of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8501, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanC-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with β2-glycoprotein I (β2GPI), implicating oxLDL/β2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/β2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/β2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and β2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of atherosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/β2GPI complexes correlated with total cholesterol and hemoglobin A1c. Thus, the generation of CRP/oxLDL/β2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/β2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis.http://www.sciencedirect.com/science/article/pii/S0022227520434303β2-glycoprotein Ioxidized LDL/β2-glycoprotein I complexesdiabetes mellitusoxidized LDL |