Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration
Summary: Inflammation and oxidative stress are major problems in peripheral nerve injury. Nanoceria can manipulate antioxidant factor expression, stimulate angiogenesis, and assist in axonal regeneration. We fabricate collagen/nanoceria/polycaprolactone (COL/NC/PCL) conduit by asymmetrical three-dim...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-02-01
|
Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219300136 |
id |
doaj-d928a0b6b73e40e4825e0576f6dc4e58 |
---|---|
record_format |
Article |
spelling |
doaj-d928a0b6b73e40e4825e0576f6dc4e582020-11-24T21:51:55ZengElsevieriScience2589-00422019-02-0112216231Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect RegenerationYun Qian0Qixin Han1Xiaotian Zhao2Hui Li3Wei-En Yuan4Cunyi Fan5Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaCenter for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, ChinaEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Medicine, University of California, 1450 Third St., San Francisco, CA 94158, USAEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authorDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Corresponding authorSummary: Inflammation and oxidative stress are major problems in peripheral nerve injury. Nanoceria can manipulate antioxidant factor expression, stimulate angiogenesis, and assist in axonal regeneration. We fabricate collagen/nanoceria/polycaprolactone (COL/NC/PCL) conduit by asymmetrical three-dimensional manufacture and find that this scaffold successfully improves Schwann cell proliferation, adhesion, and neural expression. In a 15-mm rat sciatic nerve defect model, we further confirm that the COL/NC/PCL conduit markedly alleviates inflammation and oxidative stress, improves microvessel growth, and contributes to functional, electrophysiological, and morphological nerve restoration in the long term. Our findings provide compelling evidence for future research in antioxidant nerve conduit for severe neurological defects. : Biomaterials; Nanotechnology; Neurosurgery Subject Areas: Biomaterials, Nanotechnology, Neurosurgeryhttp://www.sciencedirect.com/science/article/pii/S2589004219300136 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun Qian Qixin Han Xiaotian Zhao Hui Li Wei-En Yuan Cunyi Fan |
spellingShingle |
Yun Qian Qixin Han Xiaotian Zhao Hui Li Wei-En Yuan Cunyi Fan Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration iScience |
author_facet |
Yun Qian Qixin Han Xiaotian Zhao Hui Li Wei-En Yuan Cunyi Fan |
author_sort |
Yun Qian |
title |
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration |
title_short |
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration |
title_full |
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration |
title_fullStr |
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration |
title_full_unstemmed |
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration |
title_sort |
asymmetrical 3d nanoceria channel for severe neurological defect regeneration |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2019-02-01 |
description |
Summary: Inflammation and oxidative stress are major problems in peripheral nerve injury. Nanoceria can manipulate antioxidant factor expression, stimulate angiogenesis, and assist in axonal regeneration. We fabricate collagen/nanoceria/polycaprolactone (COL/NC/PCL) conduit by asymmetrical three-dimensional manufacture and find that this scaffold successfully improves Schwann cell proliferation, adhesion, and neural expression. In a 15-mm rat sciatic nerve defect model, we further confirm that the COL/NC/PCL conduit markedly alleviates inflammation and oxidative stress, improves microvessel growth, and contributes to functional, electrophysiological, and morphological nerve restoration in the long term. Our findings provide compelling evidence for future research in antioxidant nerve conduit for severe neurological defects. : Biomaterials; Nanotechnology; Neurosurgery Subject Areas: Biomaterials, Nanotechnology, Neurosurgery |
url |
http://www.sciencedirect.com/science/article/pii/S2589004219300136 |
work_keys_str_mv |
AT yunqian asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration AT qixinhan asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration AT xiaotianzhao asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration AT huili asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration AT weienyuan asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration AT cunyifan asymmetrical3dnanoceriachannelforsevereneurologicaldefectregeneration |
_version_ |
1725877749231386624 |