Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status
Summary: HIV-1 elite controllers (EC) are a rare but heterogeneous group of HIV-1-infected individuals who can suppress viral replication in the absence of antiretroviral therapy. The mechanisms of how EC achieve undetectable viral loads remain unclear. This study aimed to investigate host plasma me...
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doaj-d929e29ab8fe429fae44e809a2f09f2c2021-02-21T04:35:33ZengElsevieriScience2589-00422021-02-01242102111Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control statusMaike Sperk0Flora Mikaeloff1Sara Svensson-Akusjärvi2Shuba Krishnan3Sivasankaran Munusamy Ponnan4Anoop T. Ambikan5Piotr Nowak6Anders Sönnerborg7Ujjwal Neogi8Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, Sweden; Corresponding authorDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, SwedenDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, SwedenDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, SwedenCentre for Infectious Disease Research, Indian Institute of Science (IISc), CV Raman Avenue, Bangalore, Karnataka 560012, IndiaDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, SwedenDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institute, I73, Karolinska University Hospital, Huddinge, Stockholm 141 86, SwedenDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, Sweden; Department of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institute, I73, Karolinska University Hospital, Huddinge, Stockholm 141 86, SwedenDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Campus Flemingsberg, Stockholm 14152, Sweden; Department of Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA; Corresponding authorSummary: HIV-1 elite controllers (EC) are a rare but heterogeneous group of HIV-1-infected individuals who can suppress viral replication in the absence of antiretroviral therapy. The mechanisms of how EC achieve undetectable viral loads remain unclear. This study aimed to investigate host plasma metabolomics and targeted plasma proteomics in a Swedish HIV-1 cohort including EC and treatment-naïve viremic progressors (VP) as well as HIV-negative individuals (HC) to get insights into EC phenotype. Metabolites belonging to antioxidant defense had higher levels in EC relative to VP, whereas inflammation markers were increased in VP compared with EC. Only four plasma proteins (CCL4, CCL7, CCL20, and NOS3) were increased in EC compared with HC, and CCL20/CCR6 axis can play an essential role in EC status. Our study suggests that low-level inflammation and oxidative stress at physiological levels could be important factors contributing to elite control phenotype.http://www.sciencedirect.com/science/article/pii/S2589004221000791ImmunologyProteomicsMetabolomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maike Sperk Flora Mikaeloff Sara Svensson-Akusjärvi Shuba Krishnan Sivasankaran Munusamy Ponnan Anoop T. Ambikan Piotr Nowak Anders Sönnerborg Ujjwal Neogi |
spellingShingle |
Maike Sperk Flora Mikaeloff Sara Svensson-Akusjärvi Shuba Krishnan Sivasankaran Munusamy Ponnan Anoop T. Ambikan Piotr Nowak Anders Sönnerborg Ujjwal Neogi Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status iScience Immunology Proteomics Metabolomics |
author_facet |
Maike Sperk Flora Mikaeloff Sara Svensson-Akusjärvi Shuba Krishnan Sivasankaran Munusamy Ponnan Anoop T. Ambikan Piotr Nowak Anders Sönnerborg Ujjwal Neogi |
author_sort |
Maike Sperk |
title |
Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status |
title_short |
Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status |
title_full |
Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status |
title_fullStr |
Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status |
title_full_unstemmed |
Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status |
title_sort |
distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in hiv-1 elite control status |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2021-02-01 |
description |
Summary: HIV-1 elite controllers (EC) are a rare but heterogeneous group of HIV-1-infected individuals who can suppress viral replication in the absence of antiretroviral therapy. The mechanisms of how EC achieve undetectable viral loads remain unclear. This study aimed to investigate host plasma metabolomics and targeted plasma proteomics in a Swedish HIV-1 cohort including EC and treatment-naïve viremic progressors (VP) as well as HIV-negative individuals (HC) to get insights into EC phenotype. Metabolites belonging to antioxidant defense had higher levels in EC relative to VP, whereas inflammation markers were increased in VP compared with EC. Only four plasma proteins (CCL4, CCL7, CCL20, and NOS3) were increased in EC compared with HC, and CCL20/CCR6 axis can play an essential role in EC status. Our study suggests that low-level inflammation and oxidative stress at physiological levels could be important factors contributing to elite control phenotype. |
topic |
Immunology Proteomics Metabolomics |
url |
http://www.sciencedirect.com/science/article/pii/S2589004221000791 |
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