Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies
Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipola...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-01-01
|
Series: | Frontiers in Psychiatry |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00767/full |
id |
doaj-d92c365d9f764782887609c6fec2d183 |
---|---|
record_format |
Article |
spelling |
doaj-d92c365d9f764782887609c6fec2d1832020-11-24T22:10:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-01-01910.3389/fpsyt.2018.00767422826Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging StudiesCheng-Ta Li0Cheng-Ta Li1Cheng-Ta Li2Cheng-Ta Li3Kai-Chun Yang4Kai-Chun Yang5Wei-Chen Lin6Wei-Chen Lin7Department of Psychiatry, Taipei Veterans General Hospital, Taipei, TaiwanInstitute of Brain Science and Brain Research Center, National Yang-Ming University, Taipei, TaiwanDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanInstitute of Cognitive Neuroscience, National Central University, Jhongli, TaiwanDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanExcessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and major depressive disorder). Recently, ketamine, an N-methyl-d-aspartate antagonist, has been demonstrated to have promisingly rapid antidepressant efficacy for treatment-resistant depression. Many compounds that target the glutamate system have also become available that possess potential in the treatment of major psychiatric disorders. In this review, we update evidence from recent human studies that directly or indirectly measured glutamatergic neurotransmission and function in major psychiatric disorders using modalities such as magnetic resonance spectroscopy, positron emission tomography/single-photon emission computed tomography, and paired-pulse transcranial magnetic stimulation. The newer generation of antidepressants that target the glutamatergic system developed in human clinical studies is also reviewed.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00767/fullglutamatemajor psychiatric disordersNMDA antagonistantidepressantneuroimaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Kai-Chun Yang Kai-Chun Yang Wei-Chen Lin Wei-Chen Lin |
spellingShingle |
Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Kai-Chun Yang Kai-Chun Yang Wei-Chen Lin Wei-Chen Lin Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies Frontiers in Psychiatry glutamate major psychiatric disorders NMDA antagonist antidepressant neuroimaging |
author_facet |
Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Cheng-Ta Li Kai-Chun Yang Kai-Chun Yang Wei-Chen Lin Wei-Chen Lin |
author_sort |
Cheng-Ta Li |
title |
Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies |
title_short |
Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies |
title_full |
Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies |
title_fullStr |
Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies |
title_full_unstemmed |
Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies |
title_sort |
glutamatergic dysfunction and glutamatergic compounds for major psychiatric disorders: evidence from clinical neuroimaging studies |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2019-01-01 |
description |
Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and major depressive disorder). Recently, ketamine, an N-methyl-d-aspartate antagonist, has been demonstrated to have promisingly rapid antidepressant efficacy for treatment-resistant depression. Many compounds that target the glutamate system have also become available that possess potential in the treatment of major psychiatric disorders. In this review, we update evidence from recent human studies that directly or indirectly measured glutamatergic neurotransmission and function in major psychiatric disorders using modalities such as magnetic resonance spectroscopy, positron emission tomography/single-photon emission computed tomography, and paired-pulse transcranial magnetic stimulation. The newer generation of antidepressants that target the glutamatergic system developed in human clinical studies is also reviewed. |
topic |
glutamate major psychiatric disorders NMDA antagonist antidepressant neuroimaging |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2018.00767/full |
work_keys_str_mv |
AT chengtali glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT chengtali glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT chengtali glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT chengtali glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT kaichunyang glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT kaichunyang glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT weichenlin glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies AT weichenlin glutamatergicdysfunctionandglutamatergiccompoundsformajorpsychiatricdisordersevidencefromclinicalneuroimagingstudies |
_version_ |
1725807163058683904 |