Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese

Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese

Backgrounds Cytochrome P450 (P450) 2E1 is one of the primary enzymes responsible for the metabolism of xenobiotics, such as drugs and environmental carcinogens. The genetic polymorphisms of the CYP2E1 gene in promoter and coding regions have been identified previously in the Han Chinese population f...

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Bibliographic Details
Main Authors: Ting Wang, Huihui Du, Jingsong Ma, Lu Shen, Muyun Wei, Xianglong Zhao, Luan Chen, Mo Li, Guorong Li, Qinghe Xing, Lin He, Shengying Qin
Format: Article
Language:English
Published: PeerJ Inc. 2020-07-01
Series:PeerJ
Subjects:
Cytochrome P450 2E1 (CYP2E1)
Genetic polymorphisms
Chlorzoxazone
Metabolism
Enzyme activity
Online Access:https://peerj.com/articles/9628.pdf

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