Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy
Abstract Background Hypoxia is a characteristic of solid tumors that can lead to tumor angiogenesis and early metastasis, and addressing hypoxia presents tremendous challenges. In this work, a nanomedicine based on oxygen-absorbing perfluorotributylamine (PFA) and the bioreductive prodrug tirapazami...
Main Authors: | Hongfang Chen, You Fu, Kai Feng, Yifan Zhou, Xin Wang, Haohan Huang, Yan Chen, Wenhao Wang, Yuanjing Xu, Haijun Tian, Yuanqing Mao, Jinwu Wang, Zhiyuan Zhang |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-09-01
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Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-021-01013-0 |
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