Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

The unregulated activation of STAT3 has been demonstrated to occur in many cancers and enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors, and hormones triggers this activation by phosphorylating STAT3 at tyrosine 705. Novel imidazopyridine compounds were synth...

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Bibliographic Details
Main Authors:	Jung-Chen Su, Chuan-Hsun Chang, Szu-Hsien Wu, Chung-Wai Shiau
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	STAT3 SHP-1 HCC imidazopyridine
Online Access:	http://dx.doi.org/10.1080/14756366.2018.1497019

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