Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Preoperative chemoradiotherapy (CRT) has been actively used in Europe and the United States to treat advanced low rectal cancer, and provides excellent local control. In Japan, however, the standard treatment is lateral lymph node dissection, and to date CRT has not been actively used. In recent yea...

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Main Authors:	Kazushige Kawai, Soichiro Ishihara, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Koji Murono, Kazuhito Sasaki, Toshiaki Watanabe
Format:	Article
Language:	English
Published:	The Japan Society of Coloproctology 2017-04-01
Series:	Journal of the Anus, Rectum and Colon
Subjects:	advanced low rectal cancer chemoradiotherapy local recurrence watch and wait
Online Access:	https://www.jstage.jst.go.jp/article/jarc/1/2/1_2017-005/_pdf/-char/en

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spelling	doaj-d942f5fc9ab84a179888403f9daf35c72020-11-24T23:32:44ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532017-04-0112394410.23922/jarc.2017-0052017-005Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancerKazushige Kawai0Soichiro Ishihara1Hiroaki Nozawa2Keisuke Hata3Tomomichi Kiyomatsu4Toshiaki Tanaka5Takeshi Nishikawa6Kensuke Otani7Koji Yasuda8Koji Murono9Kazuhito Sasaki10Toshiaki Watanabe11Department of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoDepartment of Surgical Oncology, The University of TokyoPreoperative chemoradiotherapy (CRT) has been actively used in Europe and the United States to treat advanced low rectal cancer, and provides excellent local control. In Japan, however, the standard treatment is lateral lymph node dissection, and to date CRT has not been actively used. In recent years, an increasing number of Japanese institutions have been using preoperative CRT to treat locally advanced rectal cancer. In this review, we describe the latest trends in CRT under five headings: short-course or long-course radiation, efforts to improve combined chemotherapy, the addition of preoperative adjuvant chemotherapy, the watch and wait strategy, and the significance of lateral lymph node dissection in patients receiving CRT.https://www.jstage.jst.go.jp/article/jarc/1/2/1_2017-005/_pdf/-char/enadvanced low rectal cancerchemoradiotherapylocal recurrencewatch and wait
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kazushige Kawai Soichiro Ishihara Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Koji Murono Kazuhito Sasaki Toshiaki Watanabe
spellingShingle	Kazushige Kawai Soichiro Ishihara Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Koji Murono Kazuhito Sasaki Toshiaki Watanabe Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer Journal of the Anus, Rectum and Colon advanced low rectal cancer chemoradiotherapy local recurrence watch and wait
author_facet	Kazushige Kawai Soichiro Ishihara Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Koji Murono Kazuhito Sasaki Toshiaki Watanabe
author_sort	Kazushige Kawai
title	Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_short	Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_full	Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_fullStr	Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_full_unstemmed	Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_sort	recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer
publisher	The Japan Society of Coloproctology
series	Journal of the Anus, Rectum and Colon
issn	2432-3853
publishDate	2017-04-01
description	Preoperative chemoradiotherapy (CRT) has been actively used in Europe and the United States to treat advanced low rectal cancer, and provides excellent local control. In Japan, however, the standard treatment is lateral lymph node dissection, and to date CRT has not been actively used. In recent years, an increasing number of Japanese institutions have been using preoperative CRT to treat locally advanced rectal cancer. In this review, we describe the latest trends in CRT under five headings: short-course or long-course radiation, efforts to improve combined chemotherapy, the addition of preoperative adjuvant chemotherapy, the watch and wait strategy, and the significance of lateral lymph node dissection in patients receiving CRT.
topic	advanced low rectal cancer chemoradiotherapy local recurrence watch and wait
url	https://www.jstage.jst.go.jp/article/jarc/1/2/1_2017-005/_pdf/-char/en
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Recent advances in neoadjuvant chemoradiotherapy in locally advanced rectal cancer

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