Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance

Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance

There is strong evidence that impairment of mitochondrial function plays a key role in the pathogenesis of PD. The two key PD genes related to mitochondrial function are Parkin (PARK2) and PINK1 (PARK6), and also mutations in several other PD genes, including SNCA, LRRK2, DJ1, CHCHD2, and POLG, have...

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Bibliographic Details
Main Authors: Alessandra Zanon, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2018/8684906

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