A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivator...
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doaj-d9610ff90d454585a3529a1394200e582020-11-24T22:05:36ZengKarolinum PressActa Medica1211-42861805-96942005-01-01482818610.14712/18059694.2018.36A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro MethodsKamil Kuča0Jiří Cabal1Jiří Kassa2Daniel Jun3Martina Hrabinová4University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. 3. Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.https://actamedica.lfhk.cuni.cz/48/2/0081/SarinCyclosarinTabunVXObidoximePralidoxime |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamil Kuča Jiří Cabal Jiří Kassa Daniel Jun Martina Hrabinová |
spellingShingle |
Kamil Kuča Jiří Cabal Jiří Kassa Daniel Jun Martina Hrabinová A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods Acta Medica Sarin Cyclosarin Tabun VX Obidoxime Pralidoxime |
author_facet |
Kamil Kuča Jiří Cabal Jiří Kassa Daniel Jun Martina Hrabinová |
author_sort |
Kamil Kuča |
title |
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods |
title_short |
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods |
title_full |
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods |
title_fullStr |
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods |
title_full_unstemmed |
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods |
title_sort |
comparison of the potency of the oxime hlö-7 and currently used oximes (hi-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods |
publisher |
Karolinum Press |
series |
Acta Medica |
issn |
1211-4286 1805-9694 |
publishDate |
2005-01-01 |
description |
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. 3. Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6. |
topic |
Sarin Cyclosarin Tabun VX Obidoxime Pralidoxime |
url |
https://actamedica.lfhk.cuni.cz/48/2/0081/ |
work_keys_str_mv |
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