Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study
Abstract Background Age-related low-grade inflammation causing endothelial disruption influences sarcopenia, hypertension, and atherosclerosis. We reported previously that maintenance of muscle strength in elderly hypertensive men with high platelet levels is positively associated with subclinical a...
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doaj-d962e63286ab49d39afbfa00ab570d5f2020-11-25T02:35:54ZengBMCEnvironmental Health and Preventive Medicine1342-078X1347-47152018-07-0123111010.1186/s12199-018-0720-5Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional studyYuji Shimizu0Shimpei Sato1Yuko Noguchi2Jun Koyamatsu3Hirotomo Yamanashi4Miho Higashi5Mako Nagayoshi6Shin-Ya Kawashiri7Yasuhiro Nagata8Noboru Takamura9Takahiro Maeda10Department of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Island and Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Island and Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesCenter for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical SciencesDepartment of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesAbstract Background Age-related low-grade inflammation causing endothelial disruption influences sarcopenia, hypertension, and atherosclerosis. We reported previously that maintenance of muscle strength in elderly hypertensive men with high platelet levels is positively associated with subclinical atherosclerosis but not in those with low platelet levels. Since reduced tongue pressure is related to sarcopenia, tongue pressure may be associated with subclinical carotid atherosclerosis in hypertensive elderly subjects, and platelet levels may function as an indicator of the association between tongue pressure and subclinical carotid atherosclerosis. Methods We conducted a cross-sectional study of 342 hypertensive elderly Japanese men aged 60–89 who participated in an annual health check-up in 2015 and 2016. Subclinical carotid atherosclerosis was defined as a common carotid intima-media thickness (CIMT) of 1.1 mm or more. Results In the overall study population, 171 subjects demonstrated low platelets (< 21.4 × 104/μL). Tongue pressure was significantly inversely associated with subclinical carotid atherosclerosis in these subjects, but not in subjects with high platelets. The known cardiovascular risk factor adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of subclinical carotid atherosclerosis for a 1 standard deviation (SD) increment in tongue pressure (10.4 kPa) were 0.54 (0.35, 0.85) and 1.31 (0.87, 1.96), respectively. Conclusion Tongue pressure is inversely associated with subclinical carotid atherosclerosis in hypertensive elderly men with low platelet levels, but not in those with high levels. This finding may thus constitute an efficient tool for clarifying the background mechanism of age-related diseases such as sarcopenia, hypertension, and atherosclerosis.http://link.springer.com/article/10.1186/s12199-018-0720-5AtherosclerosisHypertensionPlateletsTongue pressure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuji Shimizu Shimpei Sato Yuko Noguchi Jun Koyamatsu Hirotomo Yamanashi Miho Higashi Mako Nagayoshi Shin-Ya Kawashiri Yasuhiro Nagata Noboru Takamura Takahiro Maeda |
spellingShingle |
Yuji Shimizu Shimpei Sato Yuko Noguchi Jun Koyamatsu Hirotomo Yamanashi Miho Higashi Mako Nagayoshi Shin-Ya Kawashiri Yasuhiro Nagata Noboru Takamura Takahiro Maeda Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study Environmental Health and Preventive Medicine Atherosclerosis Hypertension Platelets Tongue pressure |
author_facet |
Yuji Shimizu Shimpei Sato Yuko Noguchi Jun Koyamatsu Hirotomo Yamanashi Miho Higashi Mako Nagayoshi Shin-Ya Kawashiri Yasuhiro Nagata Noboru Takamura Takahiro Maeda |
author_sort |
Yuji Shimizu |
title |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
title_short |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
title_full |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
title_fullStr |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
title_full_unstemmed |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
title_sort |
association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study |
publisher |
BMC |
series |
Environmental Health and Preventive Medicine |
issn |
1342-078X 1347-4715 |
publishDate |
2018-07-01 |
description |
Abstract Background Age-related low-grade inflammation causing endothelial disruption influences sarcopenia, hypertension, and atherosclerosis. We reported previously that maintenance of muscle strength in elderly hypertensive men with high platelet levels is positively associated with subclinical atherosclerosis but not in those with low platelet levels. Since reduced tongue pressure is related to sarcopenia, tongue pressure may be associated with subclinical carotid atherosclerosis in hypertensive elderly subjects, and platelet levels may function as an indicator of the association between tongue pressure and subclinical carotid atherosclerosis. Methods We conducted a cross-sectional study of 342 hypertensive elderly Japanese men aged 60–89 who participated in an annual health check-up in 2015 and 2016. Subclinical carotid atherosclerosis was defined as a common carotid intima-media thickness (CIMT) of 1.1 mm or more. Results In the overall study population, 171 subjects demonstrated low platelets (< 21.4 × 104/μL). Tongue pressure was significantly inversely associated with subclinical carotid atherosclerosis in these subjects, but not in subjects with high platelets. The known cardiovascular risk factor adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of subclinical carotid atherosclerosis for a 1 standard deviation (SD) increment in tongue pressure (10.4 kPa) were 0.54 (0.35, 0.85) and 1.31 (0.87, 1.96), respectively. Conclusion Tongue pressure is inversely associated with subclinical carotid atherosclerosis in hypertensive elderly men with low platelet levels, but not in those with high levels. This finding may thus constitute an efficient tool for clarifying the background mechanism of age-related diseases such as sarcopenia, hypertension, and atherosclerosis. |
topic |
Atherosclerosis Hypertension Platelets Tongue pressure |
url |
http://link.springer.com/article/10.1186/s12199-018-0720-5 |
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