Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents
Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent surv...
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doaj-d9631c13986c43d2908a676f0a138d732020-11-25T03:30:56ZengMDPI AGCancers2072-66942020-08-01122258225810.3390/cancers12082258Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective AgentsCameron M. Callaghan0M. M. Hasibuzzaman1Samuel N. Rodman2Jessica E. Goetz3Kranti A. Mapuskar4Michael S. Petronek5Emily J. Steinbach6Benjamin J. Miller7Casey F. Pulliam8Mitchell C. Coleman9Varun V. Monga10Mohammed M. Milhem11Douglas R. Spitz12Bryan G. Allen13Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USADepartment of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USADepartment of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAInterdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52422, USADepartment of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAHolden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAHolden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USAHistorically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins—but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.https://www.mdpi.com/2072-6694/12/8/2258wound healingsoft tissue sarcomaradiotherapy complicationsradioprotective agentsneoadjuvant radiotherapylimb preservation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cameron M. Callaghan M. M. Hasibuzzaman Samuel N. Rodman Jessica E. Goetz Kranti A. Mapuskar Michael S. Petronek Emily J. Steinbach Benjamin J. Miller Casey F. Pulliam Mitchell C. Coleman Varun V. Monga Mohammed M. Milhem Douglas R. Spitz Bryan G. Allen |
spellingShingle |
Cameron M. Callaghan M. M. Hasibuzzaman Samuel N. Rodman Jessica E. Goetz Kranti A. Mapuskar Michael S. Petronek Emily J. Steinbach Benjamin J. Miller Casey F. Pulliam Mitchell C. Coleman Varun V. Monga Mohammed M. Milhem Douglas R. Spitz Bryan G. Allen Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents Cancers wound healing soft tissue sarcoma radiotherapy complications radioprotective agents neoadjuvant radiotherapy limb preservation |
author_facet |
Cameron M. Callaghan M. M. Hasibuzzaman Samuel N. Rodman Jessica E. Goetz Kranti A. Mapuskar Michael S. Petronek Emily J. Steinbach Benjamin J. Miller Casey F. Pulliam Mitchell C. Coleman Varun V. Monga Mohammed M. Milhem Douglas R. Spitz Bryan G. Allen |
author_sort |
Cameron M. Callaghan |
title |
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents |
title_short |
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents |
title_full |
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents |
title_fullStr |
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents |
title_full_unstemmed |
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents |
title_sort |
neoadjuvant radiotherapy-related wound morbidity in soft tissue sarcoma: perspectives for radioprotective agents |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-08-01 |
description |
Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins—but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity. |
topic |
wound healing soft tissue sarcoma radiotherapy complications radioprotective agents neoadjuvant radiotherapy limb preservation |
url |
https://www.mdpi.com/2072-6694/12/8/2258 |
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