SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4

SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4

Aneuploidy, the unbalanced segregation of chromosomes during cell division, is recurrent in many tumors and the cause of birth defects and genetic diseases. Centromeric chromatin represents the chromosome attachment site to the mitotic spindle, marked by specialized nucleosomes containing a specific...

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Bibliographic Details
Main Authors: Claudia Canzonetta, Stefano Vernarecci, Michele Iuliani, Cristina Marracino, Claudia Belloni, Paola Ballario, Patrizia Filetici
Format: Article
Language:English
Published: Oxford University Press 2016-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
SAGA complex
DUB-Ubp8
deubiquitylation
histone variant Cse4
centromere
mitotic stability
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.024877

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