Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe

Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe

Monoacylglycerol lipase (MAGL) is a serine hydrolase that has a key regulatory role in controlling the levels of 2-arachidonoylglycerol (2-AG), the main signaling molecule in the endocannabinoid system. Identification of selective modulators of MAGL enables both to provide new tools for investigatin...

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Bibliographic Details
Main Authors: Matteo Miceli, Silvana Casati, Roberta Ottria, Simone Di Leo, Ivano Eberini, Luca Palazzolo, Chiara Parravicini, Pierangela Ciuffreda
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
high-throughput screening
endocannabinoid
monoacylglycerol lipase
assay development
Online Access:https://www.mdpi.com/1420-3049/24/12/2241

Internet

https://www.mdpi.com/1420-3049/24/12/2241

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