Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment

<p>A new kind of microdroplet-based biological protein sensor is presented. The sensor was made by placing silicon oil on gold film with a self-assembled monolayer (SAM). The surface tension dominates the sensitivity of the sensor. Using mercaptoundecanoic acid (11-MUA) as the sensor’s SAM lay...

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Main Authors: Tzu-Chun Liao, J. Andrew Yeh
Format: Article
Language:English
Published: Chinese Institute of Automation Engineers (CIAE) & Taiwan Smart Living Space Association (SMART LISA) 2012-03-01
Series:International Journal of Automation and Smart Technology
Subjects:
Online Access:http://www.ausmt.org/index.php/AUSMT/article/view/116
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spelling doaj-d97f77e0300d4defbe08e5c1d2edda402020-11-25T01:09:46ZengChinese Institute of Automation Engineers (CIAE) & Taiwan Smart Living Space Association (SMART LISA)International Journal of Automation and Smart Technology2223-97662012-03-0121434810.5875/ausmt.v2i1.11630Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer TreatmentTzu-Chun Liao0J. Andrew Yeh1Department of Power Mechanical Engineering, National Tsing Hua UniversityInstitute of Nanoengineering and Microsystems, National Tsing-Hua University<p>A new kind of microdroplet-based biological protein sensor is presented. The sensor was made by placing silicon oil on gold film with a self-assembled monolayer (SAM). The surface tension dominates the sensitivity of the sensor. Using mercaptoundecanoic acid (11-MUA) as the sensor’s SAM layer, the sensor can detect 0.5 mg/ml, 20 μg/ml, and 0.4 μg/ml bovine serum albumin (BSA) protein solutions in a control volume of 0.5ml. The sensor’s reaction time for concentrations of 0.5 mg/ml, 20 μg/ml, and 0.4μg/ml protein solutions was 15, 60 and 120 minutes, respectively. As the size of microdroplet decreased, the change of contact angle increased.</p>http://www.ausmt.org/index.php/AUSMT/article/view/116microdropletprotein sensorself-assembled monolayer (SAM)
collection DOAJ
language English
format Article
sources DOAJ
author Tzu-Chun Liao
J. Andrew Yeh
spellingShingle Tzu-Chun Liao
J. Andrew Yeh
Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
International Journal of Automation and Smart Technology
microdroplet
protein sensor
self-assembled monolayer (SAM)
author_facet Tzu-Chun Liao
J. Andrew Yeh
author_sort Tzu-Chun Liao
title Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
title_short Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
title_full Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
title_fullStr Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
title_full_unstemmed Microdroplet Protein Sensors on a Gold Surface with a Self-assembled Monolayer Treatment
title_sort microdroplet protein sensors on a gold surface with a self-assembled monolayer treatment
publisher Chinese Institute of Automation Engineers (CIAE) & Taiwan Smart Living Space Association (SMART LISA)
series International Journal of Automation and Smart Technology
issn 2223-9766
publishDate 2012-03-01
description <p>A new kind of microdroplet-based biological protein sensor is presented. The sensor was made by placing silicon oil on gold film with a self-assembled monolayer (SAM). The surface tension dominates the sensitivity of the sensor. Using mercaptoundecanoic acid (11-MUA) as the sensor’s SAM layer, the sensor can detect 0.5 mg/ml, 20 μg/ml, and 0.4 μg/ml bovine serum albumin (BSA) protein solutions in a control volume of 0.5ml. The sensor’s reaction time for concentrations of 0.5 mg/ml, 20 μg/ml, and 0.4μg/ml protein solutions was 15, 60 and 120 minutes, respectively. As the size of microdroplet decreased, the change of contact angle increased.</p>
topic microdroplet
protein sensor
self-assembled monolayer (SAM)
url http://www.ausmt.org/index.php/AUSMT/article/view/116
work_keys_str_mv AT tzuchunliao microdropletproteinsensorsonagoldsurfacewithaselfassembledmonolayertreatment
AT jandrewyeh microdropletproteinsensorsonagoldsurfacewithaselfassembledmonolayertreatment
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