Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer

• Main Authors: Wensheng ZHOU, Wei ZHANG, Baohui HAN
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2020-02-01
• Series: Chinese Journal of Lung Cancer
• Subjects: epidermal growth factor receptor; exon 20; lung neoplasms; insertion mutation
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2020.02.07
• ISSN: 1009-3419; 1999-6187

Lung cancer has the highest morbidity and mortality among malignant tumors worldwidely. Targeted therapy related to non-small cell lung cancer (NSCLC) is the research hotspot in recent year. The emergence of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has brought a huge change in the treatment of patients with EGFR mutation. The patients with EGFR exon20 insertion are specific cohort in NSCLC. Reviewing the clinical researches to EGFR exon20 insertion mutation positive NSCLC, as well as summarizing character, testing methods and treatment, will provide a help for clinical application, bringing more benefits for patients at the same time.