Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer

Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer

Lung cancer has the highest morbidity and mortality among malignant tumors worldwidely. Targeted therapy related to non-small cell lung cancer (NSCLC) is the research hotspot in recent year. The emergence of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has brought a huge c...

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Bibliographic Details
Main Authors: Wensheng ZHOU, Wei ZHANG, Baohui HAN
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2020-02-01
Series:Chinese Journal of Lung Cancer
Subjects:
epidermal growth factor receptor
exon 20
lung neoplasms
insertion mutation
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2020.02.07
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spelling doaj-d989d0dd95414c29818882c732d0ac0f2020-11-25T02:42:33ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872020-02-0123211812610.3779/j.issn.1009-3419.2020.02.07Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung CancerWensheng ZHOU0Wei ZHANG1Baohui HAN2Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, ChinaDepartment of Pulmonary Disease, Shanghai Chest Hospital, Shanghai, 200030, ChinaDepartment of Pulmonary Disease, Shanghai Chest Hospital, Shanghai, 200030, ChinaLung cancer has the highest morbidity and mortality among malignant tumors worldwidely. Targeted therapy related to non-small cell lung cancer (NSCLC) is the research hotspot in recent year. The emergence of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has brought a huge change in the treatment of patients with EGFR mutation. The patients with EGFR exon20 insertion are specific cohort in NSCLC. Reviewing the clinical researches to EGFR exon20 insertion mutation positive NSCLC, as well as summarizing character, testing methods and treatment, will provide a help for clinical application, bringing more benefits for patients at the same time.http://dx.doi.org/10.3779/j.issn.1009-3419.2020.02.07epidermal growth factor receptorexon 20lung neoplasmsinsertion mutation
collection DOAJ
language zho
format Article
sources DOAJ
author Wensheng ZHOU
Wei ZHANG
Baohui HAN
spellingShingle Wensheng ZHOU
Wei ZHANG
Baohui HAN
Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer
epidermal growth factor receptor
exon 20
lung neoplasms
insertion mutation
author_facet Wensheng ZHOU
Wei ZHANG
Baohui HAN
author_sort Wensheng ZHOU
title Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
title_short Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
title_full Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
title_fullStr Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
title_full_unstemmed Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer
title_sort studies and progress of egfr exon 20 insertion mutation in non-small cell lung cancer
publisher Chinese Anti-Cancer Association; Chinese Antituberculosis Association
series Chinese Journal of Lung Cancer
issn 1009-3419
1999-6187
publishDate 2020-02-01
description Lung cancer has the highest morbidity and mortality among malignant tumors worldwidely. Targeted therapy related to non-small cell lung cancer (NSCLC) is the research hotspot in recent year. The emergence of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has brought a huge change in the treatment of patients with EGFR mutation. The patients with EGFR exon20 insertion are specific cohort in NSCLC. Reviewing the clinical researches to EGFR exon20 insertion mutation positive NSCLC, as well as summarizing character, testing methods and treatment, will provide a help for clinical application, bringing more benefits for patients at the same time.
topic epidermal growth factor receptor
exon 20
lung neoplasms
insertion mutation
url http://dx.doi.org/10.3779/j.issn.1009-3419.2020.02.07
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AT weizhang studiesandprogressofegfrexon20insertionmutationinnonsmallcelllungcancer
AT baohuihan studiesandprogressofegfrexon20insertionmutationinnonsmallcelllungcancer
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