Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported. Therefore, here we examined metabolic changes in six different brain regions of male and female mice under normal and T1D conditions using...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-01-01
|
Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020303512 |
id |
doaj-d98e61a762f046d7a7558b1188df2496 |
---|---|
record_format |
Article |
spelling |
doaj-d98e61a762f046d7a7558b1188df24962021-01-02T05:08:53ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-011820632074Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-modelQiaoying Jiang0Hangying Xu1Junjie Yan2Qingqing Xu3Yafei Zheng4Chen Li5Liangcai Zhao6Hongchang Gao7Hong Zheng8Institute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaCorresponding authors.; Institute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaCorresponding authors.; Institute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaType 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported. Therefore, here we examined metabolic changes in six different brain regions of male and female mice under normal and T1D conditions using an integrated method of NMR-based metabolomics and linear mixed-model, and aimed to explore sex-specific metabolic changes from normal to T1D. The results demonstrate that metabolic differences occurred in all brain regions between two genders, while the hippocampal metabolism is more likely to be affected by T1D. At the 4th week after streptozotocin treatment, brain metabolic disorders mainly occurred in the cortex and hippocampus in female T1D mice, but the striatum and hippocampus in male T1D mice. In addition, anaerobic glycolysis was significantly altered in male mice, mainly in the striatum, midbrain, hypothalamus and hippocampus, but not in female mice. We also found that female mice exhibited a hypometabolism status relative to male mice from normal to T1D. Collectively, this study suggests that T1D affected brain region-specific metabolic alterations in a sex-specific manner, and may provide a metabolic view on diabetic brain diseases between genders.http://www.sciencedirect.com/science/article/pii/S2001037020303512DiabetesGenderMetabolomicsNeurotransmitterCortexHippocampus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiaoying Jiang Hangying Xu Junjie Yan Qingqing Xu Yafei Zheng Chen Li Liangcai Zhao Hongchang Gao Hong Zheng |
spellingShingle |
Qiaoying Jiang Hangying Xu Junjie Yan Qingqing Xu Yafei Zheng Chen Li Liangcai Zhao Hongchang Gao Hong Zheng Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model Computational and Structural Biotechnology Journal Diabetes Gender Metabolomics Neurotransmitter Cortex Hippocampus |
author_facet |
Qiaoying Jiang Hangying Xu Junjie Yan Qingqing Xu Yafei Zheng Chen Li Liangcai Zhao Hongchang Gao Hong Zheng |
author_sort |
Qiaoying Jiang |
title |
Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
title_short |
Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
title_full |
Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
title_fullStr |
Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
title_full_unstemmed |
Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
title_sort |
sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model |
publisher |
Elsevier |
series |
Computational and Structural Biotechnology Journal |
issn |
2001-0370 |
publishDate |
2020-01-01 |
description |
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported. Therefore, here we examined metabolic changes in six different brain regions of male and female mice under normal and T1D conditions using an integrated method of NMR-based metabolomics and linear mixed-model, and aimed to explore sex-specific metabolic changes from normal to T1D. The results demonstrate that metabolic differences occurred in all brain regions between two genders, while the hippocampal metabolism is more likely to be affected by T1D. At the 4th week after streptozotocin treatment, brain metabolic disorders mainly occurred in the cortex and hippocampus in female T1D mice, but the striatum and hippocampus in male T1D mice. In addition, anaerobic glycolysis was significantly altered in male mice, mainly in the striatum, midbrain, hypothalamus and hippocampus, but not in female mice. We also found that female mice exhibited a hypometabolism status relative to male mice from normal to T1D. Collectively, this study suggests that T1D affected brain region-specific metabolic alterations in a sex-specific manner, and may provide a metabolic view on diabetic brain diseases between genders. |
topic |
Diabetes Gender Metabolomics Neurotransmitter Cortex Hippocampus |
url |
http://www.sciencedirect.com/science/article/pii/S2001037020303512 |
work_keys_str_mv |
AT qiaoyingjiang sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT hangyingxu sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT junjieyan sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT qingqingxu sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT yafeizheng sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT chenli sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT liangcaizhao sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT hongchanggao sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel AT hongzheng sexspecificmetabolicalterationsinthetype1diabeticbrainofmicerevealedbyanintegratedmethodofmetabolomicsandmixedmodel |
_version_ |
1724359665062510592 |