The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients

The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients

Sepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production durin...

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Main Authors: Hasan Md. Jahidul, Rabbani Raihan, Huq Shihan Mahmud Redwanul
Format: Article
Language:English
Published: Sciendo 2019-11-01
Series:The Journal of Critical Care Medicine
Subjects:
eltrombopag
sepsis
thrombocytopenia
megakaryocytes
thrombopoietin receptor
Online Access:https://doi.org/10.2478/jccm-2019-0019
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spelling doaj-d99069f48b4f46cda960528d199f69852021-09-06T19:41:34ZengSciendoThe Journal of Critical Care Medicine2393-18172019-11-015412312910.2478/jccm-2019-0019jccm-2019-0019The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill PatientsHasan Md. Jahidul0Rabbani Raihan1Huq Shihan Mahmud Redwanul2Department of Clinical Pharmacy, Square Hospitals Ltd, Dhaka, BangladeshInternal Medicine and ICU, Square Hospitals Ltd, Dhaka, BangladeshInternal Medicine and ICU, Square Hospitals Ltd, Dhaka, BangladeshSepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production during the sepsis. Eltrombopag is a thrombopoietin receptor agonist and is the second-line drug of choice in the treatment of chronic immune thrombocytopenia (ITP).https://doi.org/10.2478/jccm-2019-0019eltrombopagsepsisthrombocytopeniamegakaryocytesthrombopoietin receptor
collection DOAJ
language English
format Article
sources DOAJ
author Hasan Md. Jahidul
Rabbani Raihan
Huq Shihan Mahmud Redwanul
spellingShingle Hasan Md. Jahidul
Rabbani Raihan
Huq Shihan Mahmud Redwanul
The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
The Journal of Critical Care Medicine
eltrombopag
sepsis
thrombocytopenia
megakaryocytes
thrombopoietin receptor
author_facet Hasan Md. Jahidul
Rabbani Raihan
Huq Shihan Mahmud Redwanul
author_sort Hasan Md. Jahidul
title The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
title_short The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
title_full The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
title_fullStr The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
title_full_unstemmed The Use of High Dose Eltrombopag in the Management of Sepsis-Associated Thrombocytopenia in Critically Ill Patients
title_sort use of high dose eltrombopag in the management of sepsis-associated thrombocytopenia in critically ill patients
publisher Sciendo
series The Journal of Critical Care Medicine
issn 2393-1817
publishDate 2019-11-01
description Sepsis is a life-threatening condition, and sepsis-associated thrombocytopenia (SAT) is a common consequence of the disease where platelet count falls drastically within a very short time. Multiple key factors may cause platelet over-activation, destruction and reduction in platelet production during the sepsis. Eltrombopag is a thrombopoietin receptor agonist and is the second-line drug of choice in the treatment of chronic immune thrombocytopenia (ITP).
topic eltrombopag
sepsis
thrombocytopenia
megakaryocytes
thrombopoietin receptor
url https://doi.org/10.2478/jccm-2019-0019
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