THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES

THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES

The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling...

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Bibliographic Details
Main Authors: Giovanni Roti, Claudia Sorrentino, Antonio Cuneo
Format: Article
Language:English
Published: PAGEPress Publications 2019-06-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
NOTCH1
Targeted therapy
T-cell acute lymphoblastic leukemia
chronic lymphocytic leukemia
mantle cell lymphoma
Online Access:https://www.mjhid.org/index.php/mjhid/article/view/3954
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spelling doaj-d999151d6b4f4829af20c0bc7ff3d3442020-11-25T00:16:16ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062019-06-0111110.4084/mjhid.2019.037THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIESGiovanni Roti0Claudia Sorrentino1Antonio Cuneo2University of Parma, Department of Medicine and SurgeryUniversity of Parma, Department of Medicine and Surgery, Parma, 43126, ItalyUniversity of Ferrara, Department of Medical Sciences, Ferrara, 44121, Italy The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients’ outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia and mantle cell lymphoma. https://www.mjhid.org/index.php/mjhid/article/view/3954NOTCH1Targeted therapyT-cell acute lymphoblastic leukemiachronic lymphocytic leukemiamantle cell lymphoma
collection DOAJ
language English
format Article
sources DOAJ
author Giovanni Roti
Claudia Sorrentino
Antonio Cuneo
spellingShingle Giovanni Roti
Claudia Sorrentino
Antonio Cuneo
THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
Mediterranean Journal of Hematology and Infectious Diseases
NOTCH1
Targeted therapy
T-cell acute lymphoblastic leukemia
chronic lymphocytic leukemia
mantle cell lymphoma
author_facet Giovanni Roti
Claudia Sorrentino
Antonio Cuneo
author_sort Giovanni Roti
title THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
title_short THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
title_full THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
title_fullStr THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
title_full_unstemmed THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
title_sort therapeutic targeting of notch signaling pathway in hematological malignancies
publisher PAGEPress Publications
series Mediterranean Journal of Hematology and Infectious Diseases
issn 2035-3006
publishDate 2019-06-01
description The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients’ outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia and mantle cell lymphoma.
topic NOTCH1
Targeted therapy
T-cell acute lymphoblastic leukemia
chronic lymphocytic leukemia
mantle cell lymphoma
url https://www.mjhid.org/index.php/mjhid/article/view/3954
work_keys_str_mv AT giovanniroti therapeutictargetingofnotchsignalingpathwayinhematologicalmalignancies
AT claudiasorrentino therapeutictargetingofnotchsignalingpathwayinhematologicalmalignancies
AT antoniocuneo therapeutictargetingofnotchsignalingpathwayinhematologicalmalignancies
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