THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling...
Main Authors: | Giovanni Roti, Claudia Sorrentino, Antonio Cuneo |
---|---|
Format: | Article |
Language: | English |
Published: |
PAGEPress Publications
2019-06-01
|
Series: | Mediterranean Journal of Hematology and Infectious Diseases |
Subjects: | |
Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/3954 |
Similar Items
-
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas
by: Russell J.H. Ryan, et al.
Published: (2017-10-01) -
Targeting Notch Trafficking and Processing in Cancers
by: Luca Pagliaro, et al.
Published: (2020-09-01) -
Targeting oncogenic Notch signaling with SERCA inhibitors
by: Luca Pagliaro, et al.
Published: (2021-01-01) -
Role of Notch Receptors in Hematologic Malignancies
by: Laura Gragnani, et al.
Published: (2021-12-01) -
A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer
by: Kirsten Canté-Barrett, et al.
Published: (2020-10-01)