Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells

Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells

Silybin is a flavonolignan extracted from <i>Silybum marianum</i> (milk thistle) with hepatoprotective, antioxidant, and anti-inflammatory activity. Several studies have shown that silybin is highly effective to prevent and treat different types of cancer and that its antitumor mechanism...

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Bibliographic Details
Main Authors: Silvia Zappavigna, Daniela Vanacore, Stefania Lama, Nicoletta Potenza, Aniello Russo, Pasquale Ferranti, Marcello Dallio, Alessandro Federico, Carmelina Loguercio, Pasquale Sperlongano, Michele Caraglia, Paola Stiuso
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
ceramides
hepatocarcinoma
miRNAs
PTEN
sorafenib
silybin
Online Access:https://www.mdpi.com/1422-0067/20/9/2190

Internet

https://www.mdpi.com/1422-0067/20/9/2190

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