Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis
Introduction Transbronchial lung cryobiopsy (TBLC) is an endoscopic technique proven to be useful in diagnostic approach to interstitial lung disease (ILD), but its role in sarcoidosis is not fully established. The aim of the present study was to assess the diagnostic yield of TBLC in sarcoidosis an...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
European Respiratory Society
2019-10-01
|
Series: | ERJ Open Research |
Online Access: | http://openres.ersjournals.com/content/5/4/00203-2019.full |
id |
doaj-d9a5bc2ea758410aad24811d075b7fe4 |
---|---|
record_format |
Article |
spelling |
doaj-d9a5bc2ea758410aad24811d075b7fe42020-11-25T01:29:34ZengEuropean Respiratory SocietyERJ Open Research2312-05412019-10-015410.1183/23120541.00203-201900203-2019Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosisMaria Jacob0Hélder Novais Bastos1Patrícia Caetano Mota2Natália Melo3Rui Cunha4José Miguel Pereira5Susana Guimarães6Conceição Souto Moura7António Morais8 Pulmonology Dept, Centro Hospitalar Universitário de São João, Porto, Portugal Pulmonology Dept, Centro Hospitalar Universitário de São João, Porto, Portugal Pulmonology Dept, Centro Hospitalar Universitário de São João, Porto, Portugal Pulmonology Dept, Centro Hospitalar Universitário de São João, Porto, Portugal Faculty of Medicine of Porto University, Porto, Portugal Faculty of Medicine of Porto University, Porto, Portugal Faculty of Medicine of Porto University, Porto, Portugal Faculty of Medicine of Porto University, Porto, Portugal Pulmonology Dept, Centro Hospitalar Universitário de São João, Porto, Portugal Introduction Transbronchial lung cryobiopsy (TBLC) is an endoscopic technique proven to be useful in diagnostic approach to interstitial lung disease (ILD), but its role in sarcoidosis is not fully established. The aim of the present study was to assess the diagnostic yield of TBLC in sarcoidosis and its safety profile. Methods Retrospective analysis of patients, evaluated in a tertiary hospital ILD outpatient clinic, who underwent TBLC in the diagnostic work-up. TBLC was performed in accordance with the 2018 expert statement from the Cryobiopsy Working Group. Results 32 patients were included (mean±sd age 47.7±12.6 years, 59.4% male) and divided into three groups: highly likely sarcoidosis (n=21), possible sarcoidosis (n=6) and unlikely sarcoidosis (n=5). A mean of 2.8±0.8 TBLCs were performed. The definitive diagnosis was established by TBLC in 20 out of 27 patients with suspected sarcoidosis. Two patients were diagnosed with sarcoidosis by other methods performed afterwards. TBLC leaded to other diagnosis as well, such as fungal infection (n=1), hypersensitivity pneumonitis (n=1) and silicosis (n=3), making the diagnostic yield for suspected sarcoidosis of TBLC of 92.6%. TBLC was also able to show compatible histological features in five patients whom sarcoidosis was not previously considered. The complications reported overall were pneumothorax in five (15.6%) patients and moderate bleeding in one (3.1%) case. Conclusion In this cohort, TBLC was a safe, reliable and useful procedure in sarcoidosis diagnosis. These results suggest that TBLC can be used successfully in those cases where a definitive diagnosis could not be reached with the usual and less-invasive diagnostic tools.http://openres.ersjournals.com/content/5/4/00203-2019.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Jacob Hélder Novais Bastos Patrícia Caetano Mota Natália Melo Rui Cunha José Miguel Pereira Susana Guimarães Conceição Souto Moura António Morais |
spellingShingle |
Maria Jacob Hélder Novais Bastos Patrícia Caetano Mota Natália Melo Rui Cunha José Miguel Pereira Susana Guimarães Conceição Souto Moura António Morais Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis ERJ Open Research |
author_facet |
Maria Jacob Hélder Novais Bastos Patrícia Caetano Mota Natália Melo Rui Cunha José Miguel Pereira Susana Guimarães Conceição Souto Moura António Morais |
author_sort |
Maria Jacob |
title |
Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
title_short |
Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
title_full |
Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
title_fullStr |
Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
title_full_unstemmed |
Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
title_sort |
diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis |
publisher |
European Respiratory Society |
series |
ERJ Open Research |
issn |
2312-0541 |
publishDate |
2019-10-01 |
description |
Introduction
Transbronchial lung cryobiopsy (TBLC) is an endoscopic technique proven to be useful in diagnostic approach to interstitial lung disease (ILD), but its role in sarcoidosis is not fully established. The aim of the present study was to assess the diagnostic yield of TBLC in sarcoidosis and its safety profile.
Methods
Retrospective analysis of patients, evaluated in a tertiary hospital ILD outpatient clinic, who underwent TBLC in the diagnostic work-up. TBLC was performed in accordance with the 2018 expert statement from the Cryobiopsy Working Group.
Results
32 patients were included (mean±sd age 47.7±12.6 years, 59.4% male) and divided into three groups: highly likely sarcoidosis (n=21), possible sarcoidosis (n=6) and unlikely sarcoidosis (n=5). A mean of 2.8±0.8 TBLCs were performed. The definitive diagnosis was established by TBLC in 20 out of 27 patients with suspected sarcoidosis. Two patients were diagnosed with sarcoidosis by other methods performed afterwards. TBLC leaded to other diagnosis as well, such as fungal infection (n=1), hypersensitivity pneumonitis (n=1) and silicosis (n=3), making the diagnostic yield for suspected sarcoidosis of TBLC of 92.6%. TBLC was also able to show compatible histological features in five patients whom sarcoidosis was not previously considered. The complications reported overall were pneumothorax in five (15.6%) patients and moderate bleeding in one (3.1%) case.
Conclusion
In this cohort, TBLC was a safe, reliable and useful procedure in sarcoidosis diagnosis. These results suggest that TBLC can be used successfully in those cases where a definitive diagnosis could not be reached with the usual and less-invasive diagnostic tools. |
url |
http://openres.ersjournals.com/content/5/4/00203-2019.full |
work_keys_str_mv |
AT mariajacob diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT heldernovaisbastos diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT patriciacaetanomota diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT nataliamelo diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT ruicunha diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT josemiguelpereira diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT susanaguimaraes diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT conceicaosoutomoura diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis AT antoniomorais diagnosticyieldandsafetyoftransbronchialcryobiopsyinsarcoidosis |
_version_ |
1725096344654184448 |