Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults
Background: We sought to assess the effects of percutaneous atrial septal defect (ASD) closure on blood biomarker levels that possibly reflect reverse cardiac remodeling. Therefore, this study investigated temporal changes in six blood biomarkers following percutaneous ASD closure in adults. Methods...
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doaj-d9a8e982f57a4553917db47cc2ea9a602020-11-25T02:26:15ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672020-10-0130100582Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adultsLaurie W. Geenen0Lucas Uchoa de Assis1Vivan J.M. Baggen2Jannet A. Eindhoven3J.A.A.E. Cuypers4Eric Boersma5Jolien W. Roos-Hesselink6Annemien E. van den Bosch7Department of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsDepartment of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsCorresponding author at: Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, Room Rg-, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands.; Department of Cardiology, Erasmus University Medical Center Rotterdam, the NetherlandsBackground: We sought to assess the effects of percutaneous atrial septal defect (ASD) closure on blood biomarker levels that possibly reflect reverse cardiac remodeling. Therefore, this study investigated temporal changes in six blood biomarkers following percutaneous ASD closure in adults. Methods: In this prospective observational cohort study, adults with ASD type II scheduled for percutaneous closure were included (2012–2016). NT-proBNP, high-sensitive troponin-T (hs-TnT), high-sensitive C-reactive protein (hs-CRP), red blood cell distribution width (RDW), growth differentiation factor-15 (GDF-15) and galectin-3 were measured one day prior to ASD closure and one day, three months and one year post ASD closure and changes were evaluated using paired T-tests. Echocardiographic measurements were obtained. Results: Fifty patients were included (median age 50 years, 62% women, 32% NYHA II). At baseline, biomarker levels were elevated in a substantial number of patients; NT-proBNP n = 22 (45%), hs-TnT n = 6 (13%) hs-CRP n = 19 (40%), galectin-3n = 5 (11%) and GDF n = 10 (23%). One day after ASD closure, significant increases of hs-TnT (median change (Δ) = 12 ng/L), hs-CRP (Δ = 1.9 mg/L), GDF-15(Δ = 129 pg/mL) and RDW (Δ = 0.1%) were observed, and a decrease in galectin-3 (Δ = −1.0 ng/mL). Consequently, 92% had at least one abnormal biomarker directly after closure. At three months biomarker levels returned to baseline, and while echocardiographic measures 1 year post closure were indicative of reverse cardiac remodeling, biomarker levels did not further decrease. Conclusion: Percutaneous ASD closure in adults leads to a direct increase in most blood biomarkers, in particular hs-CRP and hs-TnT. After three months, biomarkers returned to baseline levels and remained stable up to one year.http://www.sciencedirect.com/science/article/pii/S2352906720302803Atrial septal defectBlood biomarkersPercutaneous closureAdult congenital heart disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laurie W. Geenen Lucas Uchoa de Assis Vivan J.M. Baggen Jannet A. Eindhoven J.A.A.E. Cuypers Eric Boersma Jolien W. Roos-Hesselink Annemien E. van den Bosch |
spellingShingle |
Laurie W. Geenen Lucas Uchoa de Assis Vivan J.M. Baggen Jannet A. Eindhoven J.A.A.E. Cuypers Eric Boersma Jolien W. Roos-Hesselink Annemien E. van den Bosch Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults International Journal of Cardiology: Heart & Vasculature Atrial septal defect Blood biomarkers Percutaneous closure Adult congenital heart disease |
author_facet |
Laurie W. Geenen Lucas Uchoa de Assis Vivan J.M. Baggen Jannet A. Eindhoven J.A.A.E. Cuypers Eric Boersma Jolien W. Roos-Hesselink Annemien E. van den Bosch |
author_sort |
Laurie W. Geenen |
title |
Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
title_short |
Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
title_full |
Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
title_fullStr |
Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
title_full_unstemmed |
Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
title_sort |
evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults |
publisher |
Elsevier |
series |
International Journal of Cardiology: Heart & Vasculature |
issn |
2352-9067 |
publishDate |
2020-10-01 |
description |
Background: We sought to assess the effects of percutaneous atrial septal defect (ASD) closure on blood biomarker levels that possibly reflect reverse cardiac remodeling. Therefore, this study investigated temporal changes in six blood biomarkers following percutaneous ASD closure in adults. Methods: In this prospective observational cohort study, adults with ASD type II scheduled for percutaneous closure were included (2012–2016). NT-proBNP, high-sensitive troponin-T (hs-TnT), high-sensitive C-reactive protein (hs-CRP), red blood cell distribution width (RDW), growth differentiation factor-15 (GDF-15) and galectin-3 were measured one day prior to ASD closure and one day, three months and one year post ASD closure and changes were evaluated using paired T-tests. Echocardiographic measurements were obtained. Results: Fifty patients were included (median age 50 years, 62% women, 32% NYHA II). At baseline, biomarker levels were elevated in a substantial number of patients; NT-proBNP n = 22 (45%), hs-TnT n = 6 (13%) hs-CRP n = 19 (40%), galectin-3n = 5 (11%) and GDF n = 10 (23%). One day after ASD closure, significant increases of hs-TnT (median change (Δ) = 12 ng/L), hs-CRP (Δ = 1.9 mg/L), GDF-15(Δ = 129 pg/mL) and RDW (Δ = 0.1%) were observed, and a decrease in galectin-3 (Δ = −1.0 ng/mL). Consequently, 92% had at least one abnormal biomarker directly after closure. At three months biomarker levels returned to baseline, and while echocardiographic measures 1 year post closure were indicative of reverse cardiac remodeling, biomarker levels did not further decrease. Conclusion: Percutaneous ASD closure in adults leads to a direct increase in most blood biomarkers, in particular hs-CRP and hs-TnT. After three months, biomarkers returned to baseline levels and remained stable up to one year. |
topic |
Atrial septal defect Blood biomarkers Percutaneous closure Adult congenital heart disease |
url |
http://www.sciencedirect.com/science/article/pii/S2352906720302803 |
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