Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice.

The lysophosphatidic acid LPA₁ receptor regulates plasticity and neurogenesis in the adult hippocampus. Here, we studied whether absence of the LPA₁ receptor modulated the detrimental effects of chronic stress on hippocampal neurogenesis and spatial memory.Male LPA₁-null (NULL) and wild-type (WT) mi...

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Bibliographic Details
Main Authors: Estela Castilla-Ortega, Carolina Hoyo-Becerra, Carmen Pedraza, Jerold Chun, Fernando Rodríguez De Fonseca, Guillermo Estivill-Torrús, Luis J Santín
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3183048?pdf=render