Effect of Cationic Lipid Type in Folate-PEG-Modified Cationic Liposomes on Folate Receptor-Mediated siRNA Transfection in Tumor Cells

Effect of Cationic Lipid Type in Folate-PEG-Modified Cationic Liposomes on Folate Receptor-Mediated siRNA Transfection in Tumor Cells

In this study, we examined the effect of cationic lipid type in folate (FA)-polyethylene glycol (PEG)-modified cationic liposomes on gene-silencing effects in tumor cells using cationic liposomes/siRNA complexes (siRNA lipoplexes). We used three types of cationic cholesterol derivatives, cholesteryl...

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Bibliographic Details
Main Authors: Yoshiyuki Hattori, Satono Shimizu, Kei-ichi Ozaki, Hiraku Onishi
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Pharmaceutics
Subjects:
cationic liposome
folate
folate receptor
cationic cholesterol derivative
siRNA delivery
gene knockdown
tumor-targeting
Online Access:https://www.mdpi.com/1999-4923/11/4/181

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