Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha
The effects of spraying with kombucha and Chinese herbal kombucha were compared with treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the lungs of rats, which were then treated with one of the experimental treatments for a month. The rats were then killed a...
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Format: | Article |
Language: | English |
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Hindawi Limited
2013-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2013/790792 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nai-fang Fu Chang-hui Luo Jun-cai Wu Yan-yan Zheng Yong-jin Gan Jian-an Ling Heng-qiu Liang Dan-yu Liang Jing Xie Xiao-qin Chen Xian-jun Li Rui-hui Pan Zuo-Xing Chen Sheng-jun Jiang |
spellingShingle |
Nai-fang Fu Chang-hui Luo Jun-cai Wu Yan-yan Zheng Yong-jin Gan Jian-an Ling Heng-qiu Liang Dan-yu Liang Jing Xie Xiao-qin Chen Xian-jun Li Rui-hui Pan Zuo-Xing Chen Sheng-jun Jiang Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha Evidence-Based Complementary and Alternative Medicine |
author_facet |
Nai-fang Fu Chang-hui Luo Jun-cai Wu Yan-yan Zheng Yong-jin Gan Jian-an Ling Heng-qiu Liang Dan-yu Liang Jing Xie Xiao-qin Chen Xian-jun Li Rui-hui Pan Zuo-Xing Chen Sheng-jun Jiang |
author_sort |
Nai-fang Fu |
title |
Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha |
title_short |
Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha |
title_full |
Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha |
title_fullStr |
Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha |
title_full_unstemmed |
Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha |
title_sort |
clearance of free silica in rat lungs by spraying with chinese herbal kombucha |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
The effects of spraying with kombucha and Chinese herbal kombucha were compared with treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the lungs of rats, which were then treated with one of the experimental treatments for a month. The rats were then killed and the effects of the treatments were evaluated by examining the extent and severity of the histopathological lesions in the animals’ lungs, measuring their organ coefficients and lung collagen contents, determining the dry and wet weights of their lungs, and measuring the free silica content of the dried lungs. In addition, lavage was performed on whole lungs taken from selected rats, and the numbers and types of cells in the lavage fluid were counted. The most effective treatment in terms of the ability to reduce lung collagen content and minimize the formation of pulmonary histopathological lesions was tetrandrine treatment, followed by Chinese herbal kombucha and non-Chinese herbal kombucha. However, the lavage fluid cell counts indicated that tetrandrine treatment had severe adverse effects on macrophage viability. This effect was much less pronounced for the kombucha and Chinese herbal kombucha treatments. Moreover, the free silica levels in the lungs of animals treated with Chinese herbal kombucha were significantly lower than those for any other silica-exposed group. These preliminary results indicate that spraying with Chinese herbal kombucha preparations can effectively promote the discharge of silica dust from lung tissues. Chinese herbal kombucha inhalation may thus be a useful new treatment for silicosis and other pneumoconiosis diseases. |
url |
http://dx.doi.org/10.1155/2013/790792 |
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doaj-d9cb769856084446a030457695373a792020-11-24T21:24:55ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/790792790792Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal KombuchaNai-fang Fu0Chang-hui Luo1Jun-cai Wu2Yan-yan Zheng3Yong-jin Gan4Jian-an Ling5Heng-qiu Liang6Dan-yu Liang7Jing Xie8Xiao-qin Chen9Xian-jun Li10Rui-hui Pan11Zuo-Xing Chen12Sheng-jun Jiang13Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan 571737, ChinaTropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan 571737, ChinaTropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan 571737, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaGuangxi Zhuang Autonomous Region Institute for Chemical Toxicity Testing, Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Disease, Guangxi 530021, ChinaTropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan 571737, ChinaThe effects of spraying with kombucha and Chinese herbal kombucha were compared with treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the lungs of rats, which were then treated with one of the experimental treatments for a month. The rats were then killed and the effects of the treatments were evaluated by examining the extent and severity of the histopathological lesions in the animals’ lungs, measuring their organ coefficients and lung collagen contents, determining the dry and wet weights of their lungs, and measuring the free silica content of the dried lungs. In addition, lavage was performed on whole lungs taken from selected rats, and the numbers and types of cells in the lavage fluid were counted. The most effective treatment in terms of the ability to reduce lung collagen content and minimize the formation of pulmonary histopathological lesions was tetrandrine treatment, followed by Chinese herbal kombucha and non-Chinese herbal kombucha. However, the lavage fluid cell counts indicated that tetrandrine treatment had severe adverse effects on macrophage viability. This effect was much less pronounced for the kombucha and Chinese herbal kombucha treatments. Moreover, the free silica levels in the lungs of animals treated with Chinese herbal kombucha were significantly lower than those for any other silica-exposed group. These preliminary results indicate that spraying with Chinese herbal kombucha preparations can effectively promote the discharge of silica dust from lung tissues. Chinese herbal kombucha inhalation may thus be a useful new treatment for silicosis and other pneumoconiosis diseases.http://dx.doi.org/10.1155/2013/790792 |