Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic...
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Korean Society for Sexual Medicine and Andrology
2019-05-01
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| Series: | The World Journal of Men's Health |
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doaj-d9ce67b4c8fa4aa1a70e38de67d6850e2020-11-24T21:44:22ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902019-05-0137214815610.5534/wjmh.180071Epigenetics of Male Fertility: Effects on Assisted Reproductive TechniquesFilippo Giacone0Rossella Cannarella1Laura M. Mongioì2Angela Alamo3Rosita A. Condorelli4Aldo E. Calogero5Sandro La Vignera6Department of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDuring the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic inves-tigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.EpigenomicsInfertilitymale Infertilityassisted Reproductive techniques |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Filippo Giacone Rossella Cannarella Laura M. Mongioì Angela Alamo Rosita A. Condorelli Aldo E. Calogero Sandro La Vignera |
| spellingShingle |
Filippo Giacone Rossella Cannarella Laura M. Mongioì Angela Alamo Rosita A. Condorelli Aldo E. Calogero Sandro La Vignera Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques The World Journal of Men's Health Epigenomics Infertility male Infertility assisted Reproductive techniques |
| author_facet |
Filippo Giacone Rossella Cannarella Laura M. Mongioì Angela Alamo Rosita A. Condorelli Aldo E. Calogero Sandro La Vignera |
| author_sort |
Filippo Giacone |
| title |
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques |
| title_short |
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques |
| title_full |
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques |
| title_fullStr |
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques |
| title_full_unstemmed |
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques |
| title_sort |
epigenetics of male fertility: effects on assisted reproductive techniques |
| publisher |
Korean Society for Sexual Medicine and Andrology |
| series |
The World Journal of Men's Health |
| issn |
2287-4208 2287-4690 |
| publishDate |
2019-05-01 |
| description |
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic inves-tigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs. |
| topic |
Epigenomics Infertility male Infertility assisted Reproductive techniques |
| work_keys_str_mv |
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