Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.

Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that inhibit the cellular activity of oncogenic RET mutants at two digit nanomolar conc...

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Main Authors: Marialuisa Moccia, Qingsong Liu, Teresa Guida, Giorgia Federico, Annalisa Brescia, Zheng Zhao, Hwan Geun Choi, Xianming Deng, Li Tan, Jinhua Wang, Marc Billaud, Nathanael S Gray, Francesca Carlomagno, Massimo Santoro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4457528?pdf=render

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