Blocking IL-1 to prevent respiratory failure in COVID-19
Abstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the...
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doaj-d9d4295bbdd841b0acd5e5cd16f08b912020-11-25T03:01:33ZengBMCCritical Care1364-85352020-07-012411610.1186/s13054-020-03166-0Blocking IL-1 to prevent respiratory failure in COVID-19Frank L. van de Veerdonk0Mihai G. Netea1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical CenterDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical CenterAbstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.http://link.springer.com/article/10.1186/s13054-020-03166-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frank L. van de Veerdonk Mihai G. Netea |
spellingShingle |
Frank L. van de Veerdonk Mihai G. Netea Blocking IL-1 to prevent respiratory failure in COVID-19 Critical Care |
author_facet |
Frank L. van de Veerdonk Mihai G. Netea |
author_sort |
Frank L. van de Veerdonk |
title |
Blocking IL-1 to prevent respiratory failure in COVID-19 |
title_short |
Blocking IL-1 to prevent respiratory failure in COVID-19 |
title_full |
Blocking IL-1 to prevent respiratory failure in COVID-19 |
title_fullStr |
Blocking IL-1 to prevent respiratory failure in COVID-19 |
title_full_unstemmed |
Blocking IL-1 to prevent respiratory failure in COVID-19 |
title_sort |
blocking il-1 to prevent respiratory failure in covid-19 |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2020-07-01 |
description |
Abstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19. |
url |
http://link.springer.com/article/10.1186/s13054-020-03166-0 |
work_keys_str_mv |
AT franklvandeveerdonk blockingil1topreventrespiratoryfailureincovid19 AT mihaignetea blockingil1topreventrespiratoryfailureincovid19 |
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