Blocking IL-1 to prevent respiratory failure in COVID-19

Blocking IL-1 to prevent respiratory failure in COVID-19

Abstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the...

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Main Authors: Frank L. van de Veerdonk, Mihai G. Netea
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Critical Care
Online Access:http://link.springer.com/article/10.1186/s13054-020-03166-0
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spelling doaj-d9d4295bbdd841b0acd5e5cd16f08b912020-11-25T03:01:33ZengBMCCritical Care1364-85352020-07-012411610.1186/s13054-020-03166-0Blocking IL-1 to prevent respiratory failure in COVID-19Frank L. van de Veerdonk0Mihai G. Netea1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical CenterDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical CenterAbstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.http://link.springer.com/article/10.1186/s13054-020-03166-0
collection DOAJ
language English
format Article
sources DOAJ
author Frank L. van de Veerdonk
Mihai G. Netea
spellingShingle Frank L. van de Veerdonk
Mihai G. Netea
Blocking IL-1 to prevent respiratory failure in COVID-19
Critical Care
author_facet Frank L. van de Veerdonk
Mihai G. Netea
author_sort Frank L. van de Veerdonk
title Blocking IL-1 to prevent respiratory failure in COVID-19
title_short Blocking IL-1 to prevent respiratory failure in COVID-19
title_full Blocking IL-1 to prevent respiratory failure in COVID-19
title_fullStr Blocking IL-1 to prevent respiratory failure in COVID-19
title_full_unstemmed Blocking IL-1 to prevent respiratory failure in COVID-19
title_sort blocking il-1 to prevent respiratory failure in covid-19
publisher BMC
series Critical Care
issn 1364-8535
publishDate 2020-07-01
description Abstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.
url http://link.springer.com/article/10.1186/s13054-020-03166-0
work_keys_str_mv AT franklvandeveerdonk blockingil1topreventrespiratoryfailureincovid19
AT mihaignetea blockingil1topreventrespiratoryfailureincovid19
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