Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. [v1; ref status: indexed, http://f1000r.es/5aj]

• Main Authors: Jose Colleti Junior, Eliana Carla Armelin Benites, Gustavo Spadaccia dos Santos Fernandes, Norberto Antonio Freddi, Walter Koga, Werther Brunow de Carvalho
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2015-05-01
• Series: F1000Research
• Subjects: Bone Biology, Osteoporosis & Other Diseases of Bone; Leukemia & Proliferative Disorders of Hematic Cells; Pediatric Oncology
• Online Access: http://f1000research.com/articles/4-111/v1

Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits.