Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype

• Main Authors: Laura Giusti, Federica Ciregia, Alessandra Bonotti, Ylenia Da Valle, Elena Donadio, Claudia Boldrini, Rudy Foddis, Gino Giannaccini, Maria R. Mazzoni, Pier Aldo Canessa, Alfonso Cristaudo, Antonio Lucacchini
• Format: Article
• Language: English
• Published: Elsevier 2016-03-01
• Series: EuPA Open Proteomics
• Subjects: Mesothelioma; Biphasic; Epithelioid; Proteomics; Serum amyloid; Nrf2
• Online Access: http://www.sciencedirect.com/science/article/pii/S2212968516300071
• ISSN: 2212-9685

Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.