Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones

Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones

The organocatalytic Michael addition of malonates to symmetric unsaturated 1,4-diketones catalyzed by thiourea and squaramide derivatives with Cinchona alkaloids afforded the formation of a new C–C bond in high yields (up to 98%) and enantiomeric purities (up to 93%). The absolute configuration of t...

Full description

Bibliographic Details
Main Authors: Sergei Žari, Tiiu Kailas, Marina Kudrjashova, Mario Öeren, Ivar Järving, Toomas Tamm, Margus Lopp, Tõnis Kanger
Format: Article
Language:English
Published: Beilstein-Institut 2012-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Michael addition
non-covalent catalysis
organocatalysis
squaramide
thiourea
Online Access:https://doi.org/10.3762/bjoc.8.165

Similar Items

Similar Items