Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leuko...
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Nature Publishing Group
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02056-7 |
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doaj-d9e076b9b5cf4b79a5a972b56a383c9a2021-05-09T11:27:52ZengNature Publishing GroupCommunications Biology2399-36422021-05-01411910.1038/s42003-021-02056-7Low frequency variants associated with leukocyte telomere length in the Singapore Chinese populationXuling Chang0Resham L. Gurung1Ling Wang2Aizhen Jin3Zheng Li4Renwei Wang5Kenneth B. Beckman6Jennifer Adams-Haduch7Wee Yang Meah8Kar Seng Sim9Weng Khong Lim10Sonia Davila11Patrick Tan12Jing Xian Teo13Khung Keong Yeo14Yiamunaa M.15Sylvia Liu16Su Chi Lim17Jianjun Liu18Rob M. van Dam19Yechiel Friedlander20Woon-Puay Koh21Jian-Min Yuan22Chiea Chuen Khor23Chew-Kiat Heng24Rajkumar Dorajoo25Department of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeClinical Research Unit, Khoo Teck Puat HospitalGenome Institute of Singapore, Agency for Science, Technology, and ResearchHealth Services and Systems Research, Duke-NUS Medical School SingaporeGenome Institute of Singapore, Agency for Science, Technology, and ResearchDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghUniversity of Minnesota Genomics Center, University of MinnesotaDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghGenome Institute of Singapore, Agency for Science, Technology, and ResearchGenome Institute of Singapore, Agency for Science, Technology, and ResearchSingHealth Duke-NUS Institute of Precision MedicineSingHealth Duke-NUS Institute of Precision MedicineGenome Institute of Singapore, Agency for Science, Technology, and ResearchSingHealth Duke-NUS Institute of Precision MedicineSingHealth Duke-NUS Institute of Precision MedicineClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalGenome Institute of Singapore, Agency for Science, Technology, and ResearchSaw Swee Hock School of Public Health, National University of SingaporeSchool of Public Health and Community Medicine, Hebrew University of JerusalemHealth Services and Systems Research, Duke-NUS Medical School SingaporeDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghGenome Institute of Singapore, Agency for Science, Technology, and ResearchDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeGenome Institute of Singapore, Agency for Science, Technology, and ResearchXuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.https://doi.org/10.1038/s42003-021-02056-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo |
| spellingShingle |
Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population Communications Biology |
| author_facet |
Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo |
| author_sort |
Xuling Chang |
| title |
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_short |
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_full |
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_fullStr |
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_full_unstemmed |
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_sort |
low frequency variants associated with leukocyte telomere length in the singapore chinese population |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-05-01 |
| description |
Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer. |
| url |
https://doi.org/10.1038/s42003-021-02056-7 |
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