The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity

The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity

Iron-salen, i.e., μ-oxo-N,N′-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently identified as a new anti-cancer compound with intrinsic magnetic properties. Chelation therapy has been widely used in management of metallic poisoning, because an administration of agents that bind metals...

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Bibliographic Details
Main Authors: Masanari Umemura, Jeong-Hwan Kim, Haruki Aoyama, Yujiro Hoshino, Hidenobu Fukumura, Rina Nakakaji, Itaru Sato, Makoto Ohtake, Taisuke Akimoto, Masatoshi Narikawa, Ryo Tanaka, Takayuki Fujita, Utako Yokoyama, Masataka Taguri, Satoshi Okumura, Motohiko Sato, Haruki Eguchi, Yoshihiro Ishikawa
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Fe(Salen)
Anti-cancer
Chelate
Antidote
Deferoxamine (DFO)
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317301019

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