Microglia: A Potential Drug Target for Traumatic Axonal Injury

Microglia: A Potential Drug Target for Traumatic Axonal Injury

Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important fact...

Full description

Bibliographic Details
Main Authors: Xin Huang, Wendong You, Yuanrun Zhu, Kangli Xu, Xiaofeng Yang, Liang Wen
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2021/5554824
id doaj-d9e8bb7c0369465a8cc72a68c4dddc10
record_format Article
spelling doaj-d9e8bb7c0369465a8cc72a68c4dddc102021-05-31T00:33:46ZengHindawi LimitedNeural Plasticity1687-54432021-01-01202110.1155/2021/5554824Microglia: A Potential Drug Target for Traumatic Axonal InjuryXin Huang0Wendong You1Yuanrun Zhu2Kangli Xu3Xiaofeng Yang4Liang Wen5Department of NeurosurgeryEmergency and Trauma CenterEmergency and Trauma CenterEmergency and Trauma CenterDepartment of NeurosurgeryDepartment of NeurosurgeryTraumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.http://dx.doi.org/10.1155/2021/5554824
collection DOAJ
language English
format Article
sources DOAJ
author Xin Huang
Wendong You
Yuanrun Zhu
Kangli Xu
Xiaofeng Yang
Liang Wen
spellingShingle Xin Huang
Wendong You
Yuanrun Zhu
Kangli Xu
Xiaofeng Yang
Liang Wen
Microglia: A Potential Drug Target for Traumatic Axonal Injury
Neural Plasticity
author_facet Xin Huang
Wendong You
Yuanrun Zhu
Kangli Xu
Xiaofeng Yang
Liang Wen
author_sort Xin Huang
title Microglia: A Potential Drug Target for Traumatic Axonal Injury
title_short Microglia: A Potential Drug Target for Traumatic Axonal Injury
title_full Microglia: A Potential Drug Target for Traumatic Axonal Injury
title_fullStr Microglia: A Potential Drug Target for Traumatic Axonal Injury
title_full_unstemmed Microglia: A Potential Drug Target for Traumatic Axonal Injury
title_sort microglia: a potential drug target for traumatic axonal injury
publisher Hindawi Limited
series Neural Plasticity
issn 1687-5443
publishDate 2021-01-01
description Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.
url http://dx.doi.org/10.1155/2021/5554824
work_keys_str_mv AT xinhuang microgliaapotentialdrugtargetfortraumaticaxonalinjury
AT wendongyou microgliaapotentialdrugtargetfortraumaticaxonalinjury
AT yuanrunzhu microgliaapotentialdrugtargetfortraumaticaxonalinjury
AT kanglixu microgliaapotentialdrugtargetfortraumaticaxonalinjury
AT xiaofengyang microgliaapotentialdrugtargetfortraumaticaxonalinjury
AT liangwen microgliaapotentialdrugtargetfortraumaticaxonalinjury
_version_ 1721419646206214144

Similar Items