DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 202...
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doaj-d9ecaa6097d7474e876f746f5ab9435a2021-06-30T23:01:38ZengMDPI AGViruses1999-49152021-06-01131046104610.3390/v13061046DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 VaccinationGerardo Casucci0Domenico Acanfora1Unit of Internal Medicine, San Francesco Hospital, Viale Europa 21, 82037 Telese Terme, ItalyUnit of Internal Medicine, San Francesco Hospital, Viale Europa 21, 82037 Telese Terme, ItalyIn recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs.https://www.mdpi.com/1999-4915/13/6/1046SARS-CoV-2chimpanzee adenovirus vectored vaccinedisseminated intravascular coagulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gerardo Casucci Domenico Acanfora |
spellingShingle |
Gerardo Casucci Domenico Acanfora DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination Viruses SARS-CoV-2 chimpanzee adenovirus vectored vaccine disseminated intravascular coagulation |
author_facet |
Gerardo Casucci Domenico Acanfora |
author_sort |
Gerardo Casucci |
title |
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_short |
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_full |
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_fullStr |
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_full_unstemmed |
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_sort |
dic-like syndrome following administration of chadox1 ncov-19 vaccination |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-06-01 |
description |
In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs. |
topic |
SARS-CoV-2 chimpanzee adenovirus vectored vaccine disseminated intravascular coagulation |
url |
https://www.mdpi.com/1999-4915/13/6/1046 |
work_keys_str_mv |
AT gerardocasucci diclikesyndromefollowingadministrationofchadox1ncov19vaccination AT domenicoacanfora diclikesyndromefollowingadministrationofchadox1ncov19vaccination |
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