Relationship of serum folic acid and vitamin B12 contents with maternal endothelial injury and placental ischemia hypoxia in patients with preeclampsia

• Main Authors: Yi-Rong Wang, Yun-Lian Meng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-05-01
• Series: Journal of Hainan Medical University
• Subjects: Preeclampsia; Folic acid; Vitamin B12; Endothelial injury; Placental ischemia hypoxia
• Online Access: http://www.hnykdxxb.com/PDF/201805/14.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the relationship of serum folic acid and vitamin B12 contents with maternal endothelial injury and placental ischemia hypoxia in patients with preeclampsia. Methods: A total of 76 puerperae with preeclampsia who gave birth in this hospital between March 2016 and October 2017 were selected as the preeclampsia group, and 100 healthy puerperae who gave birth in this hospital during the same period were selected as the normal control group. The differences in serum contents of folic acid, vitamin B12, endothelial injury indexes and oxidative stress indexes were compared between the two groups 24 h before delivery. Pearson test was used to assess the intrinsic relationship of serum folic acid and vitamin B12 contents with the disease severity in puerperae with preeclampsia. Results: Serum folic acid and vitamin B12 contents of preeclampsia group were lower than those of control group; endothelial injury markers sEng, sFlt-1, ET-1 and TM contents were higher than those of control group whereas ADM content was lower than that of control group; oxidative stress indexes AOPPs and LHP contents were higher than those of normal control group whereas T-AOC content was lower than that of control group. The Pearson test showed that serum folic acid and vitamin B12 contents in puerperae with preeclampsia were directly correlated with vascular endothelial injury and placental ischemia hypoxia. Conclusion: There is folic acid and vitamin B12 deficiency in patients with preeclampsia, and it can aggravate the vascular endothelial injury and placental ischemia hypoxia.