Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility.
Approximately 25-30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5-10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare varia...
Main Authors: | Richarda M de Voer, Marc-Manuel Hahn, Robbert D A Weren, Arjen R Mensenkamp, Christian Gilissen, Wendy A van Zelst-Stams, Liesbeth Spruijt, C Marleen Kets, Junxiao Zhang, Hanka Venselaar, Lilian Vreede, Nil Schubert, Marloes Tychon, Ronny Derks, Hans K Schackert, Ad Geurts van Kessel, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg, Roland P Kuiper |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-02-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4764646?pdf=render |
Similar Items
-
DNA-testing for <it>BRCA1/2</it> prior to genetic counselling in patients with breast cancer: design of an intervention study, DNA-direct
by: Sie Aisha S, et al.
Published: (2012-05-01) -
Candidate Gene Discovery in Hereditary Colorectal Cancer and Polyposis Syndromes—Considerations for Future Studies
by: Iris B. A. W. te Paske, et al.
Published: (2020-11-01) -
Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome
by: Asima Abidi, et al.
Published: (2021-05-01) -
Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
by: Vogelaar Ingrid P, et al.
Published: (2012-12-01) -
TINF2 is a haploinsufficient tumor suppressor that limits telomere length
by: Isabelle Schmutz, et al.
Published: (2020-12-01)