Outcome of Couples with Reciprocal Translocation Carrier Undergoing the First Preimplantation Genetic Testing Cycles

• Main Authors: Cai-Xia Lei, Shuo Zhang, Hai-Yan Sun, Sai-Juan Zhu, Jing Zhou, Jing Fu, Yi-Juan Sun, Jun-Ping Wu, Yue-Ping Zhang, Xiao-Xi Sun
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Reproductive and Developmental Medicine
• Subjects: In Vitro Fertilization; Intracytoplasmic Sperm Injection; Preimplantation Genetic Diagnosis; Preimplantation Genetic Screening; Preimplantation Genetic Testing-Aneuploidy; Single-Nucleotide Polymorphism
• Online Access: http://www.repdevmed.org/article.asp?issn=2096-2924;year=2018;volume=2;issue=1;spage=30;epage=37;aulast=Lei

Background: Reciprocal translocation (RCP) causes male infertility and female recurrent pregnancy loss. Male and female carriers have different responses to meiotic disturbances. Gender difference in outcomes of the RCP couples undergoing preimplantation genetic testing (PGT) is unknown. Methods: We conducted a retrospective analysis of 238 RCP couples (124 female and 114 male carriers) divided by gender of carrier from March 2014 to March 2017. Blastocysts were divided by day 5 and day 6. Females were divided into older (≥38 years) and younger (<38 years). Logistic regression was fitted for the relationship between gender of carriers and euploidy. Euploidy rate of each group, pregnancy rate, and live birth rate between different genders were analyzed. Results: The sperm live rate, forward motile sperm rate, and normal morphology rate of serum in male RCP group were significantly decreased. The euploidy rate was 30.30% in female group and 34.90% in male group (P = 0.131); 34.50% in day 5 group and 27.50% in day 6 group (P = 0.039); 33.40% in age <38 years group and 22.40% in age ≥38 years group (P = 0.063). Day 5 (odds ratio [OR] = 1.388, 95% confidence interval [CI] = 1.012–1.904; P = 0.042) and younger age (OR = 1.753, 95% CI = 0.97–3.17; P = 0.063) were associated with euploidy. The clinical pregnancy rate (37.90% vs. 41.20%), ongoing pregnancy rate (33.10% vs. 37.70%), and live birth rate (25.80% vs. 31.60%) per initiated were not significantly different in two gender groups. Conclusions: Although gender influence is not significant, couples with male carrier showed better clinical outcomes. The embryo growing rate and female age are important predictions estimating euploidy in RCP couples.