Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model....
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2016-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11007 |
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doaj-da0cd1920a214e60a77818aaf0b365f22021-05-11T10:35:48ZengNature Publishing GroupNature Communications2041-17232016-03-017111310.1038/ncomms11007Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonistBenjamin Cao0Zhen Zhang1Jochen Grassinger2Brenda Williams3Chad K. Heazlewood4Quentin I. Churches5Simon A. James6Songhui Li7Thalia Papayannopoulou8Susan K. Nilsson9Biomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingDepartment of Hematology and Oncology, University Hospital RegensbergBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingDepartment of Medicine/Hematology, University of Washington SeattleBiomedical Manufacturing, CSIRO ManufacturingMobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.https://doi.org/10.1038/ncomms11007 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson |
spellingShingle |
Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist Nature Communications |
author_facet |
Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson |
author_sort |
Benjamin Cao |
title |
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist |
title_short |
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist |
title_full |
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist |
title_fullStr |
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist |
title_full_unstemmed |
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist |
title_sort |
therapeutic targeting and rapid mobilization of endosteal hsc using a small molecule integrin antagonist |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-03-01 |
description |
Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model. |
url |
https://doi.org/10.1038/ncomms11007 |
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