Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model....

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Main Authors: Benjamin Cao, Zhen Zhang, Jochen Grassinger, Brenda Williams, Chad K. Heazlewood, Quentin I. Churches, Simon A. James, Songhui Li, Thalia Papayannopoulou, Susan K. Nilsson
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11007
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spelling doaj-da0cd1920a214e60a77818aaf0b365f22021-05-11T10:35:48ZengNature Publishing GroupNature Communications2041-17232016-03-017111310.1038/ncomms11007Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonistBenjamin Cao0Zhen Zhang1Jochen Grassinger2Brenda Williams3Chad K. Heazlewood4Quentin I. Churches5Simon A. James6Songhui Li7Thalia Papayannopoulou8Susan K. Nilsson9Biomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingDepartment of Hematology and Oncology, University Hospital RegensbergBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingDepartment of Medicine/Hematology, University of Washington SeattleBiomedical Manufacturing, CSIRO ManufacturingMobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.https://doi.org/10.1038/ncomms11007
collection DOAJ
language English
format Article
sources DOAJ
author Benjamin Cao
Zhen Zhang
Jochen Grassinger
Brenda Williams
Chad K. Heazlewood
Quentin I. Churches
Simon A. James
Songhui Li
Thalia Papayannopoulou
Susan K. Nilsson
spellingShingle Benjamin Cao
Zhen Zhang
Jochen Grassinger
Brenda Williams
Chad K. Heazlewood
Quentin I. Churches
Simon A. James
Songhui Li
Thalia Papayannopoulou
Susan K. Nilsson
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
Nature Communications
author_facet Benjamin Cao
Zhen Zhang
Jochen Grassinger
Brenda Williams
Chad K. Heazlewood
Quentin I. Churches
Simon A. James
Songhui Li
Thalia Papayannopoulou
Susan K. Nilsson
author_sort Benjamin Cao
title Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_short Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_full Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_fullStr Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_full_unstemmed Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_sort therapeutic targeting and rapid mobilization of endosteal hsc using a small molecule integrin antagonist
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.
url https://doi.org/10.1038/ncomms11007
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