MRI detection of the malignant transformation of stem cells through reporter gene expression driven by a tumor-specific promoter

MRI detection of the malignant transformation of stem cells through reporter gene expression driven by a tumor-specific promoter

Abstract Background Existing evidence has shown that mesenchymal stem cells (MSCs) can undergo malignant transformation, which is a serious limitation of MSC-based therapies. Therefore, it is necessary to monitor malignant transformation of MSCs via a noninvasive imaging method. Although reporter ge...

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Bibliographic Details
Main Authors: Jun Sun, Jie Huang, Guangcheng Bao, Helin Zheng, Cui Wang, Jie Wei, Yuanqiao Fu, Jiawen Qiu, Yifan Liao, Jinhua Cai
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Promoter of progression elevated gene-3
Ferritin heavy chain
Magnetic resonance imaging
Stem cells
Malignant transformation
Online Access:https://doi.org/10.1186/s13287-021-02359-w

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