Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications

Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological effects and promising therapeutic applications. I...

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Main Authors:	Patricia Cosme, Ana B. Rodríguez, Javier Espino, María Garrido
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Antioxidants
Subjects:	antioxidant activity bioavailability flavonoids health benefits phenolic compounds
Online Access:	https://www.mdpi.com/2076-3921/9/12/1263

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spelling	doaj-da19c6fd1e554e80b4496eb62d2a11132020-12-13T00:00:55ZengMDPI AGAntioxidants2076-39212020-12-0191263126310.3390/antiox9121263Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting ApplicationsPatricia Cosme0Ana B. Rodríguez1Javier Espino2María Garrido3Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, SpainNeuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, SpainNeuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, SpainNeuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, SpainPhenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological effects and promising therapeutic applications. In this review, we discuss the importance of phenolic compounds’ bioavailability to accomplish their physiological functions, and highlight main factors affecting such parameter throughout metabolism of phenolics, from absorption to excretion. Besides, we give an updated overview of the health benefits of phenolic compounds, which are mainly linked to both their direct (e.g., free-radical scavenging ability) and indirect (e.g., by stimulating activity of antioxidant enzymes) antioxidant properties. Such antioxidant actions reportedly help them to prevent chronic and oxidative stress-related disorders such as cancer, cardiovascular and neurodegenerative diseases, among others. Last, we comment on development of cutting-edge delivery systems intended to improve bioavailability and enhance stability of phenolic compounds in the human body.https://www.mdpi.com/2076-3921/9/12/1263antioxidant activitybioavailabilityflavonoidshealth benefitsphenolic compounds
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Patricia Cosme Ana B. Rodríguez Javier Espino María Garrido
spellingShingle	Patricia Cosme Ana B. Rodríguez Javier Espino María Garrido Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications Antioxidants antioxidant activity bioavailability flavonoids health benefits phenolic compounds
author_facet	Patricia Cosme Ana B. Rodríguez Javier Espino María Garrido
author_sort	Patricia Cosme
title	Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
title_short	Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
title_full	Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
title_fullStr	Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
title_full_unstemmed	Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
title_sort	plant phenolics: bioavailability as a key determinant of their potential health-promoting applications
publisher	MDPI AG
series	Antioxidants
issn	2076-3921
publishDate	2020-12-01
description	Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological effects and promising therapeutic applications. In this review, we discuss the importance of phenolic compounds’ bioavailability to accomplish their physiological functions, and highlight main factors affecting such parameter throughout metabolism of phenolics, from absorption to excretion. Besides, we give an updated overview of the health benefits of phenolic compounds, which are mainly linked to both their direct (e.g., free-radical scavenging ability) and indirect (e.g., by stimulating activity of antioxidant enzymes) antioxidant properties. Such antioxidant actions reportedly help them to prevent chronic and oxidative stress-related disorders such as cancer, cardiovascular and neurodegenerative diseases, among others. Last, we comment on development of cutting-edge delivery systems intended to improve bioavailability and enhance stability of phenolic compounds in the human body.
topic	antioxidant activity bioavailability flavonoids health benefits phenolic compounds
url	https://www.mdpi.com/2076-3921/9/12/1263
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Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications

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