Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection
Abnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. However, limited data are available on cancer patients. Coagulation indexes and inflammation parameters in 57 cancer patients with SAR...
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doaj-da26460a292246e1a8b48c572a03c2752020-11-25T02:55:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-07-011010.3389/fonc.2020.01345565221Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 InfectionBei Xiong0Tao Liu1Ping Luo2Yongchang Wei3Yi Zhou4Minghui Liu5Yongxi Zhang6Hanlun Wang7Xiaochun Zhang8Xinghuan Wang9Fuling Zhou10Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Urology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Radiation Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Infection Disease, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Urology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaAbnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. However, limited data are available on cancer patients. Coagulation indexes and inflammation parameters in 57 cancer patients with SARS-CoV-2 infection with different severity were retrospectively analyzed. We found that D-dimer levels were increased in 33 patients (57.9%, median: 790 ng/mL). Compared with ordinary type patients, severe and critical ill patients had decreased MPV values (P = 0.006), prolonged PT (median: 13.3 vs. 11.5 vs. 11.4 s, P < 0.001), significant higher D-dimer levels (median: 2,400 vs. 940 vs. 280 ng/mL, P < 0.001), higher PCT levels (median: 0.17 vs. 0.055 vs. 0.045 ng/mL, P = 0.002), higher IL-6 (median: 20.6 vs. 2.3 vs. 3.0 pg/mL, P = 0.040), and decreased PaO2 (median: 68 vs. 84 vs. 96 mm Hg, P < 0.001). Importantly, three patients, one severe and two critical ill type, with increased D-dimer survived after anticoagulant therapy with continuous heparin infusion. Increased D-dimer levels positively correlated with increased PCT levels (r = 0.456, P = 0.002) and IL-6 levels (r = 0.501, P = 0.045). A negative correlation between D-dimer levels and PaO2 levels (r = −0.654, P = 0.021) were also existed. Cancer patients with COVID-19 showed prominent hypercoagulability associated with severe inflammation, anticoagulation therapy might be useful to improve the prognosis and should be immediately used after the onset of hypercoagulability.https://www.frontiersin.org/article/10.3389/fonc.2020.01345/fullSARS-CoV-2COVID-19cancerD-dimerhypercoagulability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bei Xiong Tao Liu Ping Luo Yongchang Wei Yi Zhou Minghui Liu Yongxi Zhang Hanlun Wang Xiaochun Zhang Xinghuan Wang Fuling Zhou |
spellingShingle |
Bei Xiong Tao Liu Ping Luo Yongchang Wei Yi Zhou Minghui Liu Yongxi Zhang Hanlun Wang Xiaochun Zhang Xinghuan Wang Fuling Zhou Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection Frontiers in Oncology SARS-CoV-2 COVID-19 cancer D-dimer hypercoagulability |
author_facet |
Bei Xiong Tao Liu Ping Luo Yongchang Wei Yi Zhou Minghui Liu Yongxi Zhang Hanlun Wang Xiaochun Zhang Xinghuan Wang Fuling Zhou |
author_sort |
Bei Xiong |
title |
Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection |
title_short |
Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection |
title_full |
Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection |
title_fullStr |
Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection |
title_full_unstemmed |
Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection |
title_sort |
prominent hypercoagulability associated with inflammatory state among cancer patients with sars-cov-2 infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-07-01 |
description |
Abnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. However, limited data are available on cancer patients. Coagulation indexes and inflammation parameters in 57 cancer patients with SARS-CoV-2 infection with different severity were retrospectively analyzed. We found that D-dimer levels were increased in 33 patients (57.9%, median: 790 ng/mL). Compared with ordinary type patients, severe and critical ill patients had decreased MPV values (P = 0.006), prolonged PT (median: 13.3 vs. 11.5 vs. 11.4 s, P < 0.001), significant higher D-dimer levels (median: 2,400 vs. 940 vs. 280 ng/mL, P < 0.001), higher PCT levels (median: 0.17 vs. 0.055 vs. 0.045 ng/mL, P = 0.002), higher IL-6 (median: 20.6 vs. 2.3 vs. 3.0 pg/mL, P = 0.040), and decreased PaO2 (median: 68 vs. 84 vs. 96 mm Hg, P < 0.001). Importantly, three patients, one severe and two critical ill type, with increased D-dimer survived after anticoagulant therapy with continuous heparin infusion. Increased D-dimer levels positively correlated with increased PCT levels (r = 0.456, P = 0.002) and IL-6 levels (r = 0.501, P = 0.045). A negative correlation between D-dimer levels and PaO2 levels (r = −0.654, P = 0.021) were also existed. Cancer patients with COVID-19 showed prominent hypercoagulability associated with severe inflammation, anticoagulation therapy might be useful to improve the prognosis and should be immediately used after the onset of hypercoagulability. |
topic |
SARS-CoV-2 COVID-19 cancer D-dimer hypercoagulability |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.01345/full |
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