The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?
The human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts it...
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doaj-da356ced09094fc7855ea25de47480da2020-11-25T03:49:57ZengMDPI AGNutrients2072-66432020-08-01122648264810.3390/nu12092648The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?Felice Crocetto0Mariarosaria Boccellino1Biagio Barone2Erika Di Zazzo3Antonella Sciarra4Giovanni Galasso5Giuliana Settembre6Lucio Quagliuolo7Ciro Imbimbo8Silvia Boffo9Italo Francesco Angelillo10Marina Di Domenico11Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples “Federico II”, 80135 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples “Federico II”, 80135 Naples, ItalyDepartment of Health Science “V. Tiberio”, 86100 Campobasso, ItalyDepartment of Translational Medical Sciences, University of Campania Luigi Vanvitelli, 80135 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples “Federico II”, 80135 Naples, ItalySbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, 19122 PA, USADepartment of Experimental Medicine, University of Campania Luigi Vanvitelli, 80135 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, ItalyThe human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts its influence on prostate cancer initiation and/or progression mechanisms through the regulation of chronic inflammation, apoptotic processes, cytokines, and hormonal production in response to different pathogenic noxae. Additionally, therapies’ and drugs’ responses are influenced in their efficacy and tolerability by microbiota composition. Due to this complex potential interconnection between prostate cancer and microbiota, exploration and understanding of the involved relationships is pivotal to evaluate a potential therapeutic application in clinical practice. Several natural compounds, moreover, seem to have relevant effects, directly or mediated by microbiota, on urologic health, posing the human microbiota at the crossroad between prostatic inflammation and prostate cancer development. Here, we aim to analyze the most recent evidence regarding the possible crosstalk between prostate, microbiome, and inflammation.https://www.mdpi.com/2072-6643/12/9/2648prostate cancermicrobiotanutraceutical compounds |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Felice Crocetto Mariarosaria Boccellino Biagio Barone Erika Di Zazzo Antonella Sciarra Giovanni Galasso Giuliana Settembre Lucio Quagliuolo Ciro Imbimbo Silvia Boffo Italo Francesco Angelillo Marina Di Domenico |
spellingShingle |
Felice Crocetto Mariarosaria Boccellino Biagio Barone Erika Di Zazzo Antonella Sciarra Giovanni Galasso Giuliana Settembre Lucio Quagliuolo Ciro Imbimbo Silvia Boffo Italo Francesco Angelillo Marina Di Domenico The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? Nutrients prostate cancer microbiota nutraceutical compounds |
author_facet |
Felice Crocetto Mariarosaria Boccellino Biagio Barone Erika Di Zazzo Antonella Sciarra Giovanni Galasso Giuliana Settembre Lucio Quagliuolo Ciro Imbimbo Silvia Boffo Italo Francesco Angelillo Marina Di Domenico |
author_sort |
Felice Crocetto |
title |
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? |
title_short |
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? |
title_full |
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? |
title_fullStr |
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? |
title_full_unstemmed |
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? |
title_sort |
crosstalk between prostate cancer and microbiota inflammation: nutraceutical products are useful to balance this interplay? |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-08-01 |
description |
The human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts its influence on prostate cancer initiation and/or progression mechanisms through the regulation of chronic inflammation, apoptotic processes, cytokines, and hormonal production in response to different pathogenic noxae. Additionally, therapies’ and drugs’ responses are influenced in their efficacy and tolerability by microbiota composition. Due to this complex potential interconnection between prostate cancer and microbiota, exploration and understanding of the involved relationships is pivotal to evaluate a potential therapeutic application in clinical practice. Several natural compounds, moreover, seem to have relevant effects, directly or mediated by microbiota, on urologic health, posing the human microbiota at the crossroad between prostatic inflammation and prostate cancer development. Here, we aim to analyze the most recent evidence regarding the possible crosstalk between prostate, microbiome, and inflammation. |
topic |
prostate cancer microbiota nutraceutical compounds |
url |
https://www.mdpi.com/2072-6643/12/9/2648 |
work_keys_str_mv |
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