Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify po...
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EDP Sciences
2015-01-01
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| Series: | EPJ Web of Conferences |
| Online Access: | http://dx.doi.org/10.1051/epjconf/20158302011 |
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doaj-da3795bcd7f647bf9bd5eebdca47efa82021-08-02T16:04:07ZengEDP SciencesEPJ Web of Conferences2100-014X2015-01-01830201110.1051/epjconf/20158302011epjconf-Qens-Wins2014_02011Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopyMartins Murillo L.Orecchini AndreaAguilera Luis0Eckert Juergen1Embs Jan2Matic Aleksander3Saeki Margarida J.4Bordallo Heloisa N.5Department of Applied Physics, Chalmers University of TechnologyDepartment of Chemistry, University of South FloridaLaboratory for Neutron Scattering, Paul Scherrer InstituteDepartment of Applied Physics, Chalmers University of TechnologyInstituto de Biociências - Universidade Estadual Paulista – CP. 510Niels Bohr Institute, University of Copenhagen The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug. http://dx.doi.org/10.1051/epjconf/20158302011 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Martins Murillo L. Orecchini Andrea Aguilera Luis Eckert Juergen Embs Jan Matic Aleksander Saeki Margarida J. Bordallo Heloisa N. |
| spellingShingle |
Martins Murillo L. Orecchini Andrea Aguilera Luis Eckert Juergen Embs Jan Matic Aleksander Saeki Margarida J. Bordallo Heloisa N. Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy EPJ Web of Conferences |
| author_facet |
Martins Murillo L. Orecchini Andrea Aguilera Luis Eckert Juergen Embs Jan Matic Aleksander Saeki Margarida J. Bordallo Heloisa N. |
| author_sort |
Martins Murillo L. |
| title |
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| title_short |
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| title_full |
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| title_fullStr |
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| title_full_unstemmed |
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| title_sort |
encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy |
| publisher |
EDP Sciences |
| series |
EPJ Web of Conferences |
| issn |
2100-014X |
| publishDate |
2015-01-01 |
| description |
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
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| url |
http://dx.doi.org/10.1051/epjconf/20158302011 |
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